55750-48-6, Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Compound 10 (CAS Reg. No. 73259-81-1, available from Chem-Impex, 50.0 mg, 0.245 mmol) was dissolved in 2 mL saturated sodium bicarbonate solution at RT. Compound 9 (CAS Reg. No. 55750-48-6, available from Sigma-Aldridge, 38.0 mg, 0.245 mmol) was added at 5 C. It took about 10 min for the suspension to become homogeneous and the reaction vessel was left in a freezer overnight. The mixture was acidified with 10% TFA and purified by preparative chromatography to give compound 7 (25.0 mg, 0.088 mmol, 35.9% yield) as a mixture of rotamers. MS: (+) m/z, 284.9 (M+l). For the major rotamer: NMR (400 MHz, METHANOL-di) delta ppm 1.38 (s, 9 H), 3.56 – 3.66 (m, 1 H), 3.69 – 3.80 (m, 1 H), 4.80 (dd, (0142) J=10.4, 4.3 Hz, 1 H), 6.87 (s, 2 H). Preparative chromatography conditions: Column: XBridge BEH Shield RP18 OBD Prep Column, 13thetaAlpha, 5 muiotaeta, 30 mm X 150 mm, 1/pkg [186002990], flow rate: 40 mL /min, 23 min gradient: 5-50%, acetonitrile (with 0.1% TFA)/ water (with 0.1% TFA). Fractions were collected at 20% acetonitrile in water.
The synthetic route of 55750-48-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; CONG, Qiang; GANGWAR, Sanjeev; RANGAN, Vangipuram S.; SUNG, Mei-Chen; (36 pag.)WO2017/196598; (2017); A1;,
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