With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.69778-83-2,4-Methoxy-1H-pyrrol-2(5H)-one,as a common compound, the synthetic route is as follows.
EXAMPLE 1 (Z)-4-methoxy-5-isobutylidene-3-pyrrolin-2-one (IV, R2 =H, R3 =Me, R4 =isopropyl) 35.9 g of 4-methoxy-3-pyrrolin-2-one (II, R3 =Me) was dissolved in 2000 ml of 4 n aqueous sodium hydroxide solution and was mixed at 50 C. within 30 minutes with a solution of 24.0 g of isobutyraldehyde in 675 ml of methanol. After 1 hour, 675 ml of water was added and the reaction mixture was cooled to 0 C. The resulting product was filtered off, washed with water and dried in a vacuum at 40 C. The filtrate was extracted with dichloromethane. The yield was 39.7 g plus 10.1 g from the dichloromethane extract (99.4 percent total yield). Other data for the product was: Melting point: 139 to 141 C., colorless crystals 1 H-NMR: delta=8.64 (br.s, 1H), 5.30 (d, 1H), 5.14 (d, 1H), 3.85 (s, 3H), 2.67 (m, 1H), 1.11 (d, 6H)
The synthetic route of 69778-83-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Lonza, Ltd.; US4983743; (1991); A;,
Pyrroline – Wikipedia
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