With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.
NaOAc (0.42 mL, 5.10 mmol) and thiophenol(0.91 mL, 9.02 mmol) were added to a stirred solutionof 3,4-dibromomaleimide (1.00 g, 3.92 mmol) in MeOH (40 mL). After 30 min of stirring at roomtemperature the mixture was concentrated to dryness and the crude residue waspurified by column chromatography (5% to 20% EtOAc/petrol) to yield the title compound as a yellow solid (0.90mg, 2.87 mmol, 73%). m.p. 108-110 C; nmax(cm-1) 3274, 1774, 1719, 1329,1042, 741; dH (CDCl3, 600MHz) 7.29 (2H, t, J = 7.2 Hz, ArH), 7.25 (4H, t, J = 7.2Hz, ArH), 7.19 (4H, d, J = 7.2 Hz, ArH); dC (CDCl3, 150 MHz) 166.3 (s), 136.7(s), 131.9 (d), 129.1 (d), 128.8 (s), 128.6 (d); HRMS (EI): Mass calculated for C16H10O2NS2312.0153, observed: 312.0153.
The synthetic route of 1122-10-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Castaneda, Lourdes; Wright, Zoe V.F.; Marculescu, Cristina; Tran, Trang M.; Chudasama, Vijay; Maruani, Antoine; Hull, Elizabeth A.; Nunes, Joao P.M.; Fitzmaurice, Richard J.; Smith, Mark E.B.; Jones, Lyn H.; Caddick, Stephen; Baker, James R.; Tetrahedron Letters; vol. 54; 27; (2013); p. 3493 – 3495;,
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