With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.25021-08-3,2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid,as a common compound, the synthetic route is as follows.
Complex (OC-6-44)-acetatodiamminedichloridohydroxidoplatinum(IV), 3, (56?mg, 0.15?mmol) suspended in 1?mL of DMF was added to a solution of activated ligand HL (0.74?mmol) in 1?mL of DMF (see above). The mixture reacted for 24?h at room temperature. Then, the precipitate was discarded by centrifugation and the solvent removed by means of a rotary evaporator. The residue was dissolved in 200?muL of methanol and precipitated by adding 25?mL of diethyl ether. The crystalline solid is washed with diethyl ether. Yield: 43?mg (56%). 1H NMR (DMSO-d6) delta: 1.91 (s, 3H, CH3), 4.17 (s, 2H, CH2), 6.49 (m, 6H, NH3), 7.09 (s, 2H, CH) ppm; 13C NMR (DMSO-d6) delta: 22.5 (CH3), 47.5 (CH2), 134.8 (CH), 170.4 (NC(O)), 174.4 (OC(O)CH2), 178.0 (OC(O)CH3) ppm; 195Pt NMR (DMSO-d6) delta: 1230?ppm. ESI-MS (positive ion mode): 514?m/z [M?+?H]+, calcd for C8H14Cl2N3O6Pt [M?+?H]+ 514?m/z. Elem. Anal. found: C 18.96; H 2.78; N 7.93%; calcd. for C8H13Cl2N3O6Pt: C 18.72; H 2.55; N 8.19%.
As the paragraph descriping shows that 25021-08-3 is playing an increasingly important role.
Reference£º
Article; Gabano, Elisabetta; Perin, Elena; Bonzani, Diego; Ravera, Mauro; Inorganica Chimica Acta; vol. 488; (2019); p. 195 – 200;,
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