With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17057-04-4,4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid,as a common compound, the synthetic route is as follows.
Derivative 1 was synthesized using a modified procedure reported by Willner etal. [51] as it is also described by Lau etal. [31]. A cooled suspension (0 C) of molecule 4 (211 mg, 0.97 mmol) in methylene chloride (4.5 mL) was treated with triethylamine (190 muL, 1.36 mmol) and isobutyl chloroformate (175 muL, 1.34 mmol). The mixture was stirred for 1 h at 0 C and at room temperature (22 C) for about 1 h. Afterwards, tert-butyl carbazate (128 mg, 0.97 mmol) dissolved in methylene chloride (0.8 mL) was added dropwise to the mixture and stirred for an additional 12 h at 22 C. The reaction mixture was diluted with ethyl acetate (55 mL) and methylene chloride (20 mL) and washed twice with saturated NaHCO3 (2 ¡Á 50 mL), twice with 0.1 N HCI (2 ¡Á 50 mL), twice with saturated NaCl (2 ¡Á 50 mL), and finally with H2O (50 mL). The organic phase was dried (MgSO4) and evaporated to give crude derivative 1. The product was purified by flash chromatography, using a mixture of hexanes/acetone (3/2), to yield 173 mg (54 %) of 1.
17057-04-4 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid 86925, apyrrolines compound, is more and more widely used in various.
Reference£º
Article; Hamelin-Morrissette, Jovane; Cloutier, Suzie; Girouard, Julie; Belgorosky, Denise; Eijan, Ana Maria; Legault, Jean; Reyes-Moreno, Carlos; Berube, Gervais; European Journal of Medicinal Chemistry; vol. 96; (2015); p. 259 – 268;,
Pyrroline – Wikipedia
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