With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.134272-64-3,N-(2-Aminoethyl)maleimide Hydrochloride,as a common compound, the synthetic route is as follows.
N-2-ethyl-malimide hydrochloride salt (1.0 g, 5.66 mmol) in THF (50 ml) cooled at -78 C. was added phosphoryl trichloride (0.86 g, 5.66 mmol). After stirred at -78 C. for 2 h to form (2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)phosphoramidic dichloride (2), 3-aminopropanoic acid (0.51 g, 5.70 mmol) in the mixture of THF/H2O (2:1, 30 ml) and triethylamine (1.0 g, 9.90 mmol) was added to the solution. The resulting mixture was stirred at RT for 3 h, concentrated under vacuum and purified on the SiO2 column eluted with H2O/CH3CN (1:201:10) to afford the title compound 4 (1.28 g, 78% yield). ESI MS m/z-C9H13N3O6P (M-H), cacld. 290.06. found 290.10.
As the paragraph descriping shows that 134272-64-3 is playing an increasingly important role.
Reference£º
Patent; SUZHOU M-CONJ BIOTECH CO., LTD; Zhao, Robert Yongxin; US2015/284416; (2015); A1;,
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