With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.151038-94-7,6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide 2,2,2-trifluoroacetate,as a common compound, the synthetic route is as follows.
EMCH-TFA (3 equiv) and 0.75 equiv TFA were added to an anhydrous ethanol (dried by 3 A molecular sieves, superactivated by heating to 150 C under a vacuum of 0.1 Torr) solution (8.57 mL) of PPD (15 mg, 18.3 muiotaetaomicron, 1 equiv) and stirred under a nitrogen atmosphere overnight at room temperature. The extent of the reaction was monitored by HPLC (Method 1.3). Once 90% complete by HPLC, the solution was evaporated to dryness and the residue redissolved in anhydrous DMSO. PPD/PPD-EMCH was precipitated by adding at least 3 volumes of PBS (pH 7.4). The precipitate was washed with dH20 (pH > 6.5) and redissolved in DMSO. The precipitation was repeated three times, followed by further purification by radial chromatography, eluting PPD and PPD-EMCH with 90: 1 and 20: 1 chloroform:methanol, repectively. NMR spectra were obtained at 56C in deuteriochloroform (Figure 5)., 151038-94-7
The synthetic route of 151038-94-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE; KOCH, Tad, H.; BARTHEL, Benjamin, L.; ROWAN, Alexander, R.H.; WO2012/167255; (2012); A1;,
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