Some tips on 69778-83-2

69778-83-2 4-Methoxy-1H-pyrrol-2(5H)-one 574769, apyrrolines compound, is more and more widely used in various.

69778-83-2, 4-Methoxy-1H-pyrrol-2(5H)-one is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,69778-83-2

EXAMPLE 3 (Z)-4-methoxy-5-propylidene-3-pyrrolin-2-one (IV, R2 =H, R3 =Me, R4 =Et) 23.9 g of 4-methoxy-3-pyrrolin-2-one (94.6 percent) in 1360 ml of 4 n sodium hydroxide solution and 13.2 g of propionaldehyde (97 percent) in 330 ml of methanol were reacted as described in Example 1. Data for the product was: Yield: 18.0 g (58.8 percent) Melting point: 119¡ã to 127¡ã C., colorless crystals 1 H-NMR: delta=8.62 (br.s, 1H) 5.43 (t, 1H), 5.12 (d,1H), 3.84 (s, 3H), 2.27 (m, 2H), 1.12 (t, 3H)

69778-83-2 4-Methoxy-1H-pyrrol-2(5H)-one 574769, apyrrolines compound, is more and more widely used in various.

Reference£º
Patent; Lonza, Ltd.; US4983743; (1991); A;,
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1-Pyrroline | C4H7N – PubChem

Some tips on 69778-83-2

69778-83-2 4-Methoxy-1H-pyrrol-2(5H)-one 574769, apyrrolines compound, is more and more widely used in various.

69778-83-2, 4-Methoxy-1H-pyrrol-2(5H)-one is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,69778-83-2

Example 3 Interconversion Between Compounds (VI) A solution of 4-methoxy-3-pyrrolin-2-one (3 g; 26.52 mmols) in absolute ethanol (60 ml) is treated with sodium ethoxyde (2.17 g; 31.82 mmols) under nitrogen atmosphere. The solution is refluxed for 2 hours and then poured into a 30percent NaH2 PO4 solution (200 ml) The resulting mixture is extracted with ethyl acetate (3*150 ml) and the organic phase is shacked with brine, dried over sodium sulphate and evaporated to dryness to obtain 4-ethoxy-3-pyrrolin-2-one (2.19 g; 17.24 mmols). Yield: 65percent. 1 NMR (400 mhz, CDCl3), ppm: 1.38 (3H, t), 3.89 (2H, s), 4.01 (2H, q), 5.03 (1H, s), 6.15 (1H, bs).

69778-83-2 4-Methoxy-1H-pyrrol-2(5H)-one 574769, apyrrolines compound, is more and more widely used in various.

Reference£º
Patent; Pharmacia & UpJohn S.p.A.; US5847127; (1998); A;,
Pyrroline – Wikipedia
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Some tips on 73286-71-2

73286-71-2 N-Boc-2-pyrroline 10844857, apyrrolines compound, is more and more widely used in various.

73286-71-2, N-Boc-2-pyrroline is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,73286-71-2

General procedure: To a stirred solution of p-chlorobenzaldehyde, 6 (1.16 g, 8.25 mmol) and aniline 5 (1.83 g, 8.23 mmol) in anhydrous CH3CN (30 mL), 4 A molecular sieves and Sc(OTf)3 (0.81 g, 1.65 mmol) were added. The mixture was stirred at room temperature under argon atmosphere for 5 min and then treated with a solution of enamine 4 (1.50 g, 8.01 mmol) in anhydrous CH3CN (16 mL). The resulting suspension was stirred at room temperature under argon atmosphere for 3 days. Then, the resulting mixture was diluted with sat. aq. NaHCO3 (150 mL) and extracted with EtOAc (3 * 200 mL). The combined organic extracts were dried over anhydrous Na2SO4 and evaporated under reduced pressure to give a solid residue (4.71 g), mainly consisting of a diastereomeric mixture of octahydrobenzonaphthyridines 7, which was used in the next step without further purification. To a solution of crude diastereomeric mixture 7 (4.58 g of a crude of 4.71 g) in anhydrous CHCl3 (150 mL), DDQ (4.85 g, 21.4 mmol) was added. The reaction mixture was stirred at room temperature under argon atmosphere overnight, diluted with CH2Cl2 (150 mL) and washed with sat. aq. NaHCO3 (3 * 250 mL). The combined organic extracts were dried over anhydrous Na2SO4 and evaporated under reduced pressure to give a solid residue (5.33 g), which was purified through column chromatography (35-70 mum silica gel, hexane/EtOAc mixtures, gradient elution). On elution with hexane/1-Benzyl-9-(tert-butoxycarbonylaminomethyl)-5-(4-chlorophenyl)-1,2,3,4-tetrahydro-2-oxobenzo[h][1,6]naphthyridine 8EtOAc 80:20, compound 8 (1.94 g, 47% yield) was isolated as a white solid; Rf 0.83 (hexane/EtOAc 1:1). A solution of 8 (30 mg, 0.06 mmol) in CH2Cl2 (5 mL) was filtered through a 0.2 mum PTFE filter and evaporated at reduced pressure. The solid was washed with pentane (3 * 5 mL) to give, after drying under standard conditions, the analytical sample of 8 (27 mg):

73286-71-2 N-Boc-2-pyrroline 10844857, apyrrolines compound, is more and more widely used in various.

Reference£º
Article; Di Pietro, Ornella; Vicente-Garcia, Esther; Taylor, Martin C.; Berenguer, Diana; Viayna, Elisabet; Lanzoni, Anna; Sola, Irene; Sayago, Helena; Riera, Cristina; Fisa, Roser; Clos, M. Victoria; Perez, Belen; Kelly, John M.; Lavilla, Rodolfo; Munoz-Torrero, Diego; European Journal of Medicinal Chemistry; vol. 105; (2015); p. 120 – 137;,
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Downstream synthetic route of 1122-10-7

As the paragraph descriping shows that 1122-10-7 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.,1122-10-7

To a stirred solution of 2,3-dibromomaleimide (255 mg, 1.0 mmol) in CH2Cl2 (20 mL) Et3N(2.0 mmol, 278 mL) and 1-mercapto-11-hydroxy-3,6,9-trioxaundecane (402 ml, 2.1 mmol) were added under an argon atmosphereand stirred for 3 h at room temperature. The reactionmixturewas evaporated, and the crude product was converted intoN-ethoxycarbonyl compound and worked up according to generalmethod A yielding compound 32b which was used in further stepswithout purification

As the paragraph descriping shows that 1122-10-7 is playing an increasingly important role.

Reference£º
Article; Sz?cs, Zsolt; Kelemen, Viktor; Le Thai, Son; Csavas, Magdolna; R?th, Erzsebet; Batta, Gyula; Stevaert, Annelies; Vanderlinden, Evelien; Naesens, Lieve; Herczegh, Pal; Borbas, Aniko; European Journal of Medicinal Chemistry; vol. 157; (2018); p. 1017 – 1030;,
Pyrroline – Wikipedia
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New learning discoveries about 134272-64-3

As the paragraph descriping shows that 134272-64-3 is playing an increasingly important role.

134272-64-3, N-(2-Aminoethyl)maleimide Hydrochloride is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,134272-64-3

To a solution of NHS ester, 7a (5 mg, 4.82 muetaiotaomicron) and l-(2-aminoethyl)-lH- pyrrole-2,5-dione hydrochloride (1.7 mg, 9.64 muiotaetaomicron) in anhydrous dichloromethane (200 mu) was added DIPEA (1.512 mu, 8.68 muiotaetaomicron) under nitrogen. The mixture was stirred at room temperature for 4 hours and then concentrated in vacuo. The resulting residue was purified by RP-HPLC (CI 8, CH3CN / H20). Fractions containing desired product were frozen and lyophilized to give maleimide, compound D7 (3.5 mg, 68% yield). LCMS = 4.61 min (15 min method). MS (m z): 1062.8 (M + 1)+.

As the paragraph descriping shows that 134272-64-3 is playing an increasingly important role.

Reference£º
Patent; IMMUNOGEN, INC.; MACROGENICS, INC.; HICKS, Stuart William; YODER, Nicholas C.; BARAT, Bhaswati; BONVINI, Ezio; DIEDRICH, Gundo; JOHNSON, Leslie S.; LOO, Deryk; SCRIBNER, Juniper A.; (260 pag.)WO2018/119196; (2018); A1;,
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Downstream synthetic route of 17057-04-4

As the paragraph descriping shows that 17057-04-4 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17057-04-4,4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid,as a common compound, the synthetic route is as follows.,17057-04-4

General procedure: Equimolar quantities of maleimide (2) and nitrones (5a-k and 6a-k) were refluxed in toluene (20 ml) and ethyl alcohol (5 ml) for 8-10 h (TLC monitoring using petroleum ether and hexane 1:1) followed by cooling with addition of dry ether. The products (7a-k and 8a-k) were separated out after filtration and recrystallized from toluene and petroleum ether mixture (1:1) to yield cis-isomers (7aa-7ka and 8aa-8ka). The mother liquor on further work up provided trans-isomers which were recrystallized from ethanol and diethyl ether mixture (1:1) (7aa’-7ka’ and 8aa’-8ka’) (Fig. 3).7 These stereoisomers were characterized by their 1H NMR, IR and mass spectra in addition to their melting points and elementary analysis. These stereoisomers have identical IR spectra and elemental analysis but differ in their melting points, 1H NMR and mass spectra.

As the paragraph descriping shows that 17057-04-4 is playing an increasingly important role.

Reference£º
Article; Anand, Preet; Singh, Baldev; Bioorganic and Medicinal Chemistry; vol. 20; 1; (2012); p. 521 – 530;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

Downstream synthetic route of 73286-71-2

As the paragraph descriping shows that 73286-71-2 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.73286-71-2,N-Boc-2-pyrroline,as a common compound, the synthetic route is as follows.,73286-71-2

tert-butyl-(3-trimethylsilylethynyl)-3a,4, 5,6a-tetrahydropyrrolo[3,2-d]isoxazole-6-carboxylate (Intermediate 20b, alternative procedure) A solution of tert-butyl 2,3-dihydropyrrole-1-carboxylate (500 mg, 2.95 mmol) and 3-trimethylsilylprop-2-ynal oxime (459.06 mg, 3.25 mmol) in MTBE (15 mL) was cooled to 0-5 C. while stirring. Sodium hypochlorite (2.806 mL, 5.91 mmol) was added dropwise keeping the reaction temperature below 20 C. The reaction mixture was stirred at the same temperature for 3 hours; afterwards, it was quenched with Na2SO3 solution; the two phases were separated, the organic layer was washed with water and brine, dried over Na2SO4, filtered and evaporated to dryness in vacuo. The crude residue was purified by automated flash chromatography (Biotage SP1, cartridge type SNAP25) using a gradient from petroleum ether:EtOAc 95:5 to 7:3.

As the paragraph descriping shows that 73286-71-2 is playing an increasingly important role.

Reference£º
Patent; Recordati Ireland Ltd.; Riva, Carlo; De Toma, Carlo; Angelico, Patrizia; Poggesi, Elena; Graziani, Davide; (36 pag.)US2016/185798; (2016); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

Analyzing the synthesis route of 17057-04-4

The synthetic route of 17057-04-4 has been constantly updated, and we look forward to future research findings.

17057-04-4, 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,17057-04-4

General procedure: Equimolar quantities of maleimide (2) and nitrones (5a-k and 6a-k) were refluxed in toluene (20 ml) and ethyl alcohol (5 ml) for 8-10 h (TLC monitoring using petroleum ether and hexane 1:1) followed by cooling with addition of dry ether. The products (7a-k and 8a-k) were separated out after filtration and recrystallized from toluene and petroleum ether mixture (1:1) to yield cis-isomers (7aa-7ka and 8aa-8ka). The mother liquor on further work up provided trans-isomers which were recrystallized from ethanol and diethyl ether mixture (1:1) (7aa’-7ka’ and 8aa’-8ka’) (Fig. 3).7 These stereoisomers were characterized by their 1H NMR, IR and mass spectra in addition to their melting points and elementary analysis. These stereoisomers have identical IR spectra and elemental analysis but differ in their melting points, 1H NMR and mass spectra.

The synthetic route of 17057-04-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Anand, Preet; Singh, Baldev; Bioorganic and Medicinal Chemistry; vol. 20; 1; (2012); p. 521 – 530;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

Brief introduction of 25021-08-3

The synthetic route of 25021-08-3 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.25021-08-3,2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid,as a common compound, the synthetic route is as follows.,25021-08-3

250 mg (1.07 mmol) of tert-butyl 3-[2-(2-aminoethoxy)ethoxy]propanoate, 151 mg (0.974 mmol) of 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid, 224 mg (1.46 mmol) of 1-hydroxy-1H-benzotriazole hydrate and 224 mg (1.17 mmol) of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride were dissolved in 5.0 ml of dimethylformamide. The reaction mixture was stirred at RT for 1 h. Ethyl acetate was added and the mixture was extracted twice with 5% strength citric acid solution and with saturated sodium bicarbonate solution. The organic phase was washed twice with saturated sodium chloride solution and dried over magnesium sulphate, and the solvent was evaporated under reduced pressure. The residue was purified by preparative RP-HPLC (column: Reprosil 250*40; 10mu, flow rate: 50 ml/min, MeCN/water/0.1% TFA). The solvents were evaporated under reduced pressure and the residue was dried under high vacuum. This gave 267 mg (64% of theory) of tert-butyl 3-[2-(2-{[(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetyl]amino}ethoxy)ethoxy]propanoate. LC-MS (Method 1): Rt=0.73 min; MS (ESIpos): m/z=371 (M+H)+.

The synthetic route of 25021-08-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bayer Pharma Aktiengesellschaft; LERCHEN, Hans-Georg; REBSTOCK, Anne-Sophie; CANCHO GRANDE, Yolanda; MARX, Leo; STELTE-LUDWIG, Beatrix; TERJUNG, Carsten; MAHLERT, Christoph; GREVEN, Simone; SOMMER, Anette; BERNDT, Sandra; (684 pag.)US2018/169256; (2018); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

Analyzing the synthesis route of 69778-83-2

The synthetic route of 69778-83-2 has been constantly updated, and we look forward to future research findings.

69778-83-2, 4-Methoxy-1H-pyrrol-2(5H)-one is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,69778-83-2

A. A mixture of 4-methoxy-3-pyrrolin-2-one (3 g), 1-octanol (7.4 ml) and methanesulfonic acid (0.2 g) were heated at 100¡ã C. for 2 hours under reduced pressure (40 mbars). The product was chromatographed on silica gel, eluding with 2percent methanol in methylene chloride, to give 4-octyloxy-3-pyrrolin-2-one.

The synthetic route of 69778-83-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Researche Syntex France, S.A.; US4997846; (1991); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem