With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.766-36-9,3-Ethyl-4-methyl-2,5-dihydro-1H-pyrrol-2-one,as a common compound, the synthetic route is as follows.
766-36-9, In a 50 mL round bottom flask, compound 4 (0.56 g, 2 mmol) and 3-ethyl-4-methyl-1H-pyrrol-2-one (0.275 g, 2.2 mmol) were dissolved in anhydrous ethanol (10 mL) and then DBU (1.5 mL) was added. The reaction mixture was heated at reflux for 24 h. After refluxing, the reaction mixture was cooled in an ice bath, then acetic acid (1.5 mL) was added followed by water (10 mL). The solution was chilled at?5 ¡ãC overnight, and the precipitate formed was filtered, and dried to afford the desired product (0.36 g, 1.14 mmol, 57percent). Mp 315?320 ¡ãC: 1H NMR (400 MHz, CDCl3, 30 ¡ãC) delta (ppm) 9.08 (s. 1H), 6.37 (s, 1H), 4.40 (q, J=7.20Hz, 2H), 2.76 (s, 3H), 2.45 (m, 2H), 2.15 (s, 3H), 1.43 (t, J=7. 61 Hz, 3H), 1.16 (t, J=7.61Hz, 3H); 13C NMR (100 MHz, CDCl3, 30 ¡ãC): delta (ppm) 161.7142.2, 142.1, 140.3, 137.1, 134.9, 130.1, 122.7, 117.2, 106.2, 94.1, 61.1, 16.8, 14.4, 13.1, 11.2, 9.61; IR (ATR) (cm?1): 3284 (w), 3065 (w), 2985 (w), 2870 (w), 1736 (s), 1699 (s), 1665 (w), 1453 (w), 1286 (s), 1271 (s), 1212 (m), 1106 (m), 1028 (w), 884 (w); HR-MS (EI+) C17H18N2O4 calcd: 314.1267 amu; found: 314.1445 amu.
The synthetic route of 766-36-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Jarvis, Tia; Saint-Louis, Carl Jacky; Fisch, Alexander R.; Barnes, Korry L.; Dean, Dolan; Flores, Luis A.; Hunt, Thomas F.; Munro, Lyndsay; Simmons, Tyler J.; Catalano, Vincent J.; Zhu, Lei; Schrock, Alan K.; Huggins, Michael T.; Tetrahedron; vol. 74; 14; (2018); p. 1698 – 1704;,
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