With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1334177-86-4,1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid,as a common compound, the synthetic route is as follows.
EDCI.HCI (56 mg, 0.29 mmol, 3 eq.) was added to a stirred solution of bis-amine (9) (0.123 g, 98 IJmol, 1.0 eq.) and MaldPEGOH (0.128 g, 0.22 mmol, 2.2 eq.) in CHCb (15 ml). 15 The reaction mixture was stirred at room temperature for 30 min then diluted with CHCb (50 ml) washed with H20 (1 00 ml), saturated brine (1 00 ml), dried (MgS04) and evaporated under reduced pressure. Purification by preparative HPLC followed by lyophilisation gave the product as a white foam (0.047 g, 20%). Analytical Data: LC/MS, RT 6.61 min; MS (ES+) m/z (relative intensity) 1205 ([M + 2Ht¡¤, 55).
1334177-86-4, As the paragraph descriping shows that 1334177-86-4 is playing an increasingly important role.
Reference£º
Patent; MEDIMMUNE LIMITED; DIMASI, Nazzareno; HOWARD, Philip Wilson; MASTERSON, Luke; TIBERGHIEN, Arnaud Charles; VIJAYAKRISHNAN, Balakumar; WHITE, Jason; (135 pag.)WO2019/34764; (2019); A1;,
Pyrroline – Wikipedia
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