With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.
1122-10-7, General procedure: In a 100 mL dry one-neck round bottom flask equipped with a magnetic stir bar, 3,4-dibromomaleimide (1.00 equiv) was added under N2 atmosphere. Acetone (0.62 M) and K2CO3 (1.10 equiv) were successively added and vigorously stirred for 10 min. Then, the corresponding alkylating reagent (1.20-1.40 equiv) was added to one portion. The reaction was stirred during the overnight period and quenched by solvent evaporation and extraction with AcOEt (3 x 20 mL). The crude sample from the reaction was purified by column chromatography. The spectroscopic data match perfectly with those previously described.
As the paragraph descriping shows that 1122-10-7 is playing an increasingly important role.
Reference£º
Article; Mendoza-Macias, Claudia Leticia; Solorio-Alvarado, Cesar Rogelio; Alonso-Castro, Angel Josabad; Alba-Betancourt, Clara; Deveze-Alvarez, Martha Alicia; Padilla-Vaca, Felipe; Reyes-Gualito, Arturo; Chemical Papers; vol. 74; 5; (2020); p. 1429 – 1438;,
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