With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17057-04-4,4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid,as a common compound, the synthetic route is as follows.
The synthesis of ACPM was performed essentially according to the method described in the patent [35]. The typical synthetic procedure is as follows: To a solution of CPMI (3.01 g, 13.9 mmol) and TEA (2.0 mL) in toluene (100 mL) was added DPPA (3.00 mL,13.9 mmol), and the resulting solution was stirred at room temperaturefor 48 h. After the reaction mixture was evaporated in vacuo, an oily residue was flash chromatographed over activated silica using chloroform as an eluant. The eluate was evaporated in vacuo to give ACPM as a yellow solid (2.86 g, 85.1%)., 17057-04-4
The synthetic route of 17057-04-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Ikeda, Toshiaki; Oikawa, Daisuke; Shimasaki, Toshiaki; Teramoto, Naozumi; Shibata, Mitsuhiro; Polymer; vol. 54; 13; (2013); p. 3206 – 3216;,
Pyrroline – Wikipedia
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