1334177-86-4, 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
(d) (ii S, i ia S)-4-((2S, 5S)-37-(2, 5-di oxo-2, 5-dihydro- iH-pyrrol- i-yl)-5-isopropyl-2-methyl- 4,7, 35-trioxo- 10, 13,16, 19,22,25,28,3 i-octaoxa-3, 6, 34-triazaheptatriacontanamido)benzyl iihydroxy- 7-methoxy-8-((5-(((S) – 7-methoxy-2-methyl-5-oxo-5, i ia-dihydro- iHbenzo[e]pyrrolo[i, 2-a][i, 4]diazepin-8-yl) oxy) pentyl) oxy) -2-met hyl-5-oxo- 11,1 ia-dihydro- iHbenzo[e]pyrrolo[i, 2-a][i, 4]diazepine- i 0(5H)-carboxylate (64) 1-ethyl-3-(3?-dimethylaminopropyl)carbodiimide (EDCI, 33 mg, 0.172 mmol) was added to a solution of crude 63 (0.172 mmol) and Mal-(PEG)8-acid (100 mg, 0.172 mmol) in dry dichloromethane (10 mL). The reaction was stirred for 2 hours and the presence ofstarting material was no longer observed by LC/MS. The reaction was diluted with dichloromethane and washed sequentially with water and brine. The organic phase was dried over magnesium sulphate filtered and excess dichloromethane removed by rotary evaporation under reduced pressure. The resulting residue was subjected to flash column chromatography (silica gel; 100% chloroform to 10% methanol in chloroform). Pure fractions were collected and combined and excess eluent was removed by rotary evaporation under reduced pressure to give 64 (E) (60 mg, 25% over 3 steps).
1334177-86-4, As the paragraph descriping shows that 1334177-86-4 is playing an increasingly important role.
Reference£º
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; VAN BERKEL, Patricius Henrikus Cornelis; HOWARD, Philip Wilson; WILLIAMS, David G; WO2015/159076; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem