With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1334177-86-4,1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid,as a common compound, the synthetic route is as follows.
EDCI hydrochloride (39 mg, 0.197 mmol, leq.) was added to a suspension of maleimide-PEG8-acid (117 mg, 0.197 mmol, leq.) in dry CH2CI2 (5 mL) under argon atmosphere. The mixture was stirredfor 30 mm at room temperature before PBD 13 (250 mg, 0.197 mmol) was added. Stirring was maintained until the reaction was complete (usually 5 hours). The reaction was diluted with CH2CI2 and the organic phase was washed with H20 and brine before being dried over Mg504, filtered and excess solvent removed by rotary evaporation under reduced pressure. The product was purified by careful silica gel chromatography (gradient elution: 100% CHCI3 to 9:1 v/v CHCI3/MeOH)to affordpure product 14(273.8mg, 75% yield). Analytical data: ES = 1.99 mi m/z 1863.95 [M+Na].
1334177-86-4, As the paragraph descriping shows that 1334177-86-4 is playing an increasingly important role.
Reference£º
Patent; MEDIMMUNE LIMITED; HOWARD, Philip Wilson; CAILLEAU, Thais; (159 pag.)WO2017/129652; (2017); A1;,
Pyrroline – Wikipedia
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