With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7544-75-4,3,4-Dihydro-2H-pyrrol-5-amine hydrochloride,as a common compound, the synthetic route is as follows.
Prepare 2-iminopyrrolidine hydrochloride (6. 98 g, 57.8 mmol) according to Callahan, et al., J. Med. Chem. 2002,45, 999-1001) and combine 2-bromoacetophenone (3.8 g, 19.3 mmol) with Na2CO3 (8.2 g, 77.2 mmol) in dry DMF (25 [ML)] and heat at [80C] for 18 hours. Then, cool the mixture to room temperature, add water (60 mL), and extract with EtOAc (3 x 100 mL). Concentrate the combined organic layers in vacuo, dilute the residue with ether (100 mL), and wash with cooled water (3 x 80 mL). Concentrate the organic layer in vacuo to give a white solid, 3.2 g, 89 [%] yield. MS [(ES+)] : [IIZLZ] = 185. 1 [(M+H) +], 7544-75-4
7544-75-4 3,4-Dihydro-2H-pyrrol-5-amine hydrochloride 12778905, apyrrolines compound, is more and more widely used in various.
Reference£º
Patent; ELI LILLY AND COMPANY; WO2004/14900; (2004); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem