69778-83-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.69778-83-2,4-Methoxy-1H-pyrrol-2(5H)-one,as a common compound, the synthetic route is as follows.
EXAMPLE 3 Interconversion Between Compounds (VI) A solution of 4-methoxy-3-pyrrolin-2-one (3 g; 26.52 mmols) in absolute ethanol (60 ml) is treated with sodium ethoxyde (2.17 g; 31.82 mmols) under nitrogen atmosphere. The solution is refluxed for 2 hours and then poured into a 30percent NaH2 PO4 solution (200 ml). The resulting mixture is extracted with ethyl acetate (3*150 ml) and the organic phase is shaken with brine, dried over sodium sulphate and evaporated to dryness to obtain 4-ethoxy-3-pyrrolin-2-one (2.19 g; 17.24 mmols). Yield: 65percent. 1 NMR (400 mhz, CDCl3), ppm:
The synthetic route of 69778-83-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Pharmacia & Upjohn S.p.A.; US6071947; (2000); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem