1334177-86-4, 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
EDCI.HCI (0.203 g, 1.06 mmol, 1.1 eq.) was added to a solution of compound 32 (0.86 g,0.96 mmol, 1.0 eq.) and Mal-dPEG8-OH (0.57 g, 0.96 mmol, 1.1 eq.) in dry DCM (30 mL)and CHCI3 (to give a clear solution). The clear solution was stirred at room temperature for18h. then a further portion of EDCI.HCI (0.037 g, 0.19 mmol, 0.2 eq.) was added and reaction continued for a further 24h. The reaction mixture was diluted with DCM (70 mL) washed with water (100 mL), brine (100 mL), dried (MgSO4) and evaporated under reduced pressure to give a yellow foam. Purification by flash column chromatography[CHCI3/MeOH 0% to 6% in 1% increments] gave the product as an off white foam (0.56 g,40%). Analytical Data: RT 6.13 mm; MS (ES) m/z (relative intensity) 1468 ([M + H], 20), 1334177-86-4
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Reference£º
Patent; ADC THERAPEUTICS SA; MEDIMMUNE LIMITED; VAN BERKEL, Patricius Hendrikus Cornelis; HOWARD, Philip Wilson; DUNNY, Elizabeth; HUTCHINSON, Ian; MASTERSON, Luke; (73 pag.)WO2017/137556; (2017); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem