With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.151038-94-7,6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide 2,2,2-trifluoroacetate,as a common compound, the synthetic route is as follows.
Compound 3 (69.5 mg, 0.1 mmol) was dissolved in 20 mL of absolute ethanol. Then add 6-maleimidocaproyl hydrazide trifluoroacetate(6-maleimidocaprohydrazide trifluoroacetate salt) (101.8 mg,0.3 mmol) and 5.6 muL of trifluoroacetic acid (TFA).The reaction system was stirred at room temperature for 12 hours in the dark.After the reaction, the reaction system was diluted with methanol.Purification was carried out by HPLC.HPLC purification conditions were 5-95% acetonitrile for gradient elution.The elution flow rate was 25 mL/min.Purification afforded compound 4 (TCO-Dox-Mal).
151038-94-7, 151038-94-7 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide 2,2,2-trifluoroacetate 23509306, apyrrolines compound, is more and more widely used in various.
Reference£º
Patent; Peking University; Chen Peng; Lin Feng; (14 pag.)CN109939242; (2019); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem