With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17057-04-4,4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid,as a common compound, the synthetic route is as follows.
To a solution of BP-1 (47 mg, 0.218 mmol) intetrahydrofuran (8 mL) were added N-ethylcarbodiimide hydrochloride (50 mg, 0.262 mmol), hydroxybenzotriazole (35 mg, 0.262 mmol), N-methylmorpholine (72 muL,0.654 mmol) and compound 3 (60 mg, 0.24 mmol, see the details in Supplementary Material). The mixture solution was stirred for 5 h under argon at room temperature (25 C).Solvent was evaporated under vacuum, and the residue was extracted with dichloromethane (3 ¡Á 10 mL) and deionized water. The combined organic extracts were washed with brine, dried over anhydrous Na2SO4and concentrated. The residue was purified by silica gel column chromatography (eluent: 25% ethyl acetate in n-hexane) to afford BP-3as a bright yellow solid (98 mg, 61%). 1H NMR (CDCl3,300 MHz, 293 K): delta 6.40 (2H, m), 7.05 (2H, m), 7.20 (2H,m), 9.77 (2H, s). 13C NMR (CD3CN, 75 MHz, 293 K):169.70, 169.59, 148.73, 135.12, 134.60, 134.02, 132.49,130.74, 128.05, 126.20, 123.60, 117.29, 115.82, 114.41,113.35, 50.16, 38.72. HRMS (FAB) m/z: C22H18BF2N5O3found 449.15 (M+).
17057-04-4, The synthetic route of 17057-04-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Kim, Dokyoung; Ma, Donghee; Kim, Muwoong; Jung, Yuna; Kim, Na Hee; Lee, Chiho; Cho, Seo Won; Park, Sungnam; Huh, Youngbuhm; Jung, Junyang; Ahn, Kyo Han; Journal of Fluorescence; vol. 27; 6; (2017); p. 2231 – 2238;,
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