With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17057-04-4,4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid,as a common compound, the synthetic route is as follows.
A mixture of 8.68 g (0.04 mol) of 4-(2,5-dioxo-2,5-dihydro-1-pyrrol-1-yl)benzoic acid (1), 9.52 g (0.08 mol) of thionyl chloride, 5 droplets of DMF, and 150 mL of benzene was heated under reflux for 2 h with stirring (to avoid strong shocks), and then filtered, and the light yellow filtrate was evaporated in a vacuum under heating. Yield 8.03 g (85.2%), light yellow powder, mp 165-167 (167.7-168.5 [15]). IR spectrum, nu, cm -1 : 3085 (=), 1705 (=), 890 (l), 3040, 1595, 820 (Ar-H), 890 (l). C 11 H 6 ClNO 3 .
17057-04-4, As the paragraph descriping shows that 17057-04-4 is playing an increasingly important role.
Reference£º
Article; Kolymshin; Danilov; Ignatev; Kuzmin; Russian Journal of Organic Chemistry; vol. 55; 11; (2019); p. 1686 – 1689; Zh. Org. Khim.; vol. 55; 11; (2019); p. 1717 – 1721,4;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem