With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.541-59-3,Maleimide,as a common compound, the synthetic route is as follows.,541-59-3
Example 1 Preparation of N-Methoxycarbonylmaleimide STR13 To a 1000 ml 3-neck round bottom flask was added 400 ml of ethyl acetate. The flask was placed in an ice bath and the temperature was allowed to drop to about 0 C. To the cooled flask was sequentially added with stirring 7.76 g of maleimide and 8.8 ml of N-methylmorpholine. Then, through an addition funnel was added to the stirring mixture 6.26 ml of methyl chloroformate at a rate so as not to raise the temperature above 3 C. Through the addition funnel was then added 5 ml of ethyl acetate as washing and the washing was added to the reaction mixture. The reaction mixture was stirred for 30 minutes at between 0-3 C. Thereafter, the reaction mixture was filtered through a Buchner funnel. The flask was washed 2* with 10 ml of ethyl acetate and the washings were also filtered. The resulting precipitate was washed 2*with 10 ml of ethyl acetate. The combined filtrate and washings were extracted with 100 ml of ice cold water, dried (10 g Na2 SO4), and evaporated to dryness under reduced pressure.
As the paragraph descriping shows that 541-59-3 is playing an increasingly important role.
Reference£º
Patent; Hybritech Incorporated; US5091542; (1992); A;,
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