1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To an oven-dried 250 ml round bottom flask of dibromomaleimide (DBM) (1.001 g, 3.93mmol), dry methanol (25.0 mL) was added. The solution was allowed to stir at 40 C under N2 gas. In another flask, an anhydrous solution of trifluoromethylbenzyl mercaptan (3.18 g, 16.57 mmol), TCEP (0.50 g, 1.24 mmol), and sodium acetate (1.31 g, 15.99 mmol) in dry methanol (25.0 mL) was added in 6.25 mL increments to the flask with DBM every 30 minutes under anhydrous conditions at 40 C. The reaction mixture was stirred for 4 hours. The solvents were removed in vacuo. The crude product was dissolved in dichloromethane to vacuum filtrate product of sodium acetate and solution was dried in vacuo. The crude product was purified via column chromatography and dried in vacuo to yield intermediate product (1) as a yellow powder (0.918 g, 1.92 mmol, 49%). Rf data (9:1DCM/hexanes) 0.32; 1H NMR (400 MHz CDCl3) delta data 7.63 (4H, d, CH), 7.56 (4H, d, CH), 4.49 (4H, s, CH); 13CNMR (500 MHz CDCl3) delta data 165.7, 140.7, 136.5, 129.2, 129.2, 129.2, 129.2, 125.7, 35.4; HRMS calcd forC20H12F6NO2S2 (M-) 476.0219, found: 476.0214.
1122-10-7, 1122-10-7 3,4-Dibromo-1H-pyrrole-2,5-dione 14279, apyrrolines compound, is more and more widely used in various fields.
Reference£º
Letter; Hidalgo, Francisco J.; Lorentz, Nathan A. P.; Luu, Tintin B.; Tran, Jonathan D.; Wickremasinghe, Praveen D.; Martini, Olnita; Iovine, Peter M.; Schellinger, Joan G.; Letters in Organic Chemistry; vol. 17; 2; (2020); p. 85 – 89;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem