With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.69778-83-2,4-Methoxy-1H-pyrrol-2(5H)-one,as a common compound, the synthetic route is as follows.,69778-83-2
EXAMPLE 1 Compound (IV) To a solution of 2-formyl-5-undecylpyrrole (4 g; 16.03 mmols) and 4-methoxy-3-pyrrolin-2-one (3.63 g; 32.06 mmols) in DMSO (53 ml) 2N sodium hydroxyde (45 ml) is added under nitrogen atmosphere and the mixture is stirred at 60¡ã C. for 8 hours. After dilution with water (200 ml) the yellow suspension is extracted with dichloromethane (600 ml). The organic phase is shaken with water and brine, anhydrified over anhydrous sodium sulphate and evaporated to dryness. The crude material is taken up in hexane and filtered to give 4-methoxy-5-(5-undecyl-1H-pyrrol-2-yl-methylene)-1,5-dihydro-pyrrol-2-one (4.86 g; 14.11 mmols) as a yellow crystalline solid. Yield: 88percent. 1 NMR (400 mhz, CDCl3), ppm: 0.87 (3H, m), 1.2-1.5 (16H, m), 1.72 (2H, m), 2.73 (2H, m), 3.89 (3H, s), 5.08 (1H, d, J=1.7 Hz), 5.97 (1H, dd, J=2.4 and 3.2 Hz), 6.31 (1H, s), 6.36 (1H, t, J=3.2 Hz), 10.25 (1H, bs), 10.74 (1H, bs).
As the paragraph descriping shows that 69778-83-2 is playing an increasingly important role.
Reference£º
Patent; Pharmacia & Upjohn S.p.A.; US6071947; (2000); A;,
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