With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1193-54-0,3,4-Dichloro-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.
0.83 g (5 mmol) of dichloromaleimide and 1 .25g (10 mmol) of o-aminothiophenol were added to30 ml of acetic acid, and stirred at 120 00 for 6 hours under N2. After cooling to r.t., the precipi15 tate was isolated by filtration, washed with methanol and THF. Compound 2a (1.26 g) was usedin the next step without further purification.
1193-54-0, 1193-54-0 3,4-Dichloro-1H-pyrrole-2,5-dione 14513, apyrrolines compound, is more and more widely used in various fields.
Reference£º
Patent; BASF SE; YAMATO, Hitoshi; TSUDA, Takuya; WU, Chao; WEITZ, Thomas; EUSTACHI, Michael; HEMGESBERG, Maximilian; (56 pag.)WO2016/96967; (2016); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem