With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.
Dibromomaleimide 1a, 2.0 g (7.84 mmol), was dissolved in 15 mL of anhydrous DMF, and 0.9 mL (9.51 mmol) of 4-fluoroaniline and 2 mL (11.5 mmol) of DIPEA were added. The mixture was stirred for 24 h at 50C and poured into a mixture of water and ethyl acetate. The organic layer was separated, washed with dilute aqueous HCl, and evaporated under reduced pressure, and the residue was purified by column chromatography using petroleum ether-ethyl acetate (5 : 1) as eluent. Yield 503 mg (22%), pale yellow crystals, mp 208-210C; HPLC: tau = 11.09 min, 96%. 1H NMR spectrum, delta, ppm: 7.15-7.23 m (4H), 9.60 s (1H, 4-NH), 10.96 s (1H, N1H). 13C NMR spectrum, deltaC, ppm: 80.39, 114.83 d (J = 22.8 Hz), 126.64 d (J = 8.5 Hz), 132.89, 141.73, 159.63 d (J = 242.0 Hz), 167.04, 168.4. Mass spectrum: m/z 284.9703 [M + H]+. C10H6BrFN2O2. Calculated: M + H 284.9669.
1122-10-7, The synthetic route of 1122-10-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Panov; Simonov, A. Yu.; Korolev; Russian Journal of Organic Chemistry; vol. 55; 12; (2019); p. 1847 – 1852; Zh. Org. Khim.; vol. 55; 12; (2019); p. 1850 – 1856,7;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem