With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.
General procedure: To a solution of 3,4-dibromomaleimide(1.00 g,3.90 mmol) and N-methylmorpholine (0.43mL, 3.90 mmol) in THF (35 mL), methylchloroformate (0.30 mL, 3.90 mmol) wasadded and the mixture was stirred for 20 min at room temperature. Then DCM (40mL) was added, the organic phase was washed with H2O, dried overMgSO4 and the solvent removed invacuo to yield the title product 6 asa pink power (1.18 g,3.80 mmol, 97%). m.p. 115-118 C; nmax (cm-1) 3236, 2962, 1809, 1769, 1730, 1602; dH (CDCl3, 500MHz) 4.00 (3H, s, CH3); dC (CDCl3, 125 MHz) 159.3 (s), 147.0 (s), 131.5 (s), 54.9 (q); HRMS (ES): Mass calculated for C6H3O4Br2N310.8423, observed: 310.8427
1122-10-7, The synthetic route of 1122-10-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Castaneda, Lourdes; Wright, Zoe V.F.; Marculescu, Cristina; Tran, Trang M.; Chudasama, Vijay; Maruani, Antoine; Hull, Elizabeth A.; Nunes, Joao P.M.; Fitzmaurice, Richard J.; Smith, Mark E.B.; Jones, Lyn H.; Caddick, Stephen; Baker, James R.; Tetrahedron Letters; vol. 54; 27; (2013); p. 3493 – 3495;,
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