With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.
To a solution of DBM (3.00 g, 11.7 mmol) and NMM (1.30 mL,11.7 mmol) in THF (135 mL), MCF (0.90 mL, 11.7 mmol) was added and the mixture was stirred for 1 h at room temperature. The solvent was removed in vacuo, and then DCM (100 mL) was added. The organic phase was sequentially washed with water and brine, and then dried over anhydrous MgSO4. After filtration, the solvent was removed in vacuo to generate the intermediate 1 as a pink powder in quantitative yield. The compound 1 was directly subjected to the next synthetic step without further purification., 1122-10-7
1122-10-7 3,4-Dibromo-1H-pyrrole-2,5-dione 14279, apyrrolines compound, is more and more widely used in various fields.
Reference£º
Article; Li, Zi-Long; Sun, Linhao; Ma, Jimei; Zeng, Zhen; Jiang, Hong; Polymer; vol. 84; (2016); p. 336 – 342;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem