With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.
In a 50 mL two-necked flask,NaH (30 mg, 0.75 mmol, mass fraction 60%,Dispersion in paraffin) with 5mL DMF suspension stirring,Dropwise at -5 5mLDMF dissolved in 2,3-dibromo maleimide(127.5 mg, 0.5 mmol),After reaction at low temperature for 30 min,Methyl iodide (47 [mu] L, 0.75 mmol) was added dropwise,Low temperature reaction 30min,The reaction was quenched by dropwise addition of saturated NH4Cl solution,CH2Cl2 extraction,The organic layer was evaporated to dryness,Silica gel column chromatography,Petroleum ether: ethyl acetate = 30: 1 (v / v) to give white crystals(82a)Yield 69%., 1122-10-7
As the paragraph descriping shows that 1122-10-7 is playing an increasingly important role.
Reference£º
Patent; Ocean University of China; The Key Laboratory of Chemistry Natural Products of Guizhou Province and Chinese Academy; Zhu, Weiming; Ma, Hongguang; Wang, Liping; Xu, Zhihong; Zhang, Yapeng; Wang, Yi; Liu, Peipei; Hao, Jiejie; (142 pag.)CN106146475; (2016); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem