With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2973-17-3,1-Allyl-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.
General procedure: (All the reactions were performed on 50mg scale of aldehyde.) A reaction mixture containing K2CO3 (80mol%), NHC precatalyst A (15mol%), maleimide 2 (1.5 equiv) and aldehyde 1 (1.0 equiv) in THF (2mL) under argon atmosphere was stirred at 50C for 30min to 2h. When the reaction was complete, the crude reaction mixture was allowed to attain room temperature, followed by filtration of the reaction mixture through a bed of celite. The residue was washed with ethyl acetate (5mL x 3) and the combined filtrate was evaporated under reduced pressure. The crude reaction mixture was purified by column chromatography on silica gel using solvent gradient of petroleum ether:ethyl acetate to furnish the desired products 4-13, 15-21 in 10-90% yield., 2973-17-3
The synthetic route of 2973-17-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Ahire, Milind M.; Mhaske, Santosh B.; Tetrahedron; vol. 74; 16; (2018); p. 2079 – 2084;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem