63468-63-3, 2,5-Dihydro-1H-pyrrole hydrochloride is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
63468-63-3, 2,5-Dihydropyrrole hydrochloride (0.75 g, 7.104 mmol) and sodium dicyanamide (0.63 g, 7.104 mmol) were dissolved in a butanol (20 mL) solution, and then stirred for 3 hours under reflux. After completion of the reaction was confirmed, sodium chloride formed by filtering the reaction mixture was removed, and the filtrate was then concentrated at a reduced pressure. The concentrate was dissolved in methanol (2 mL), and ethyl acetate (5 mL) was then added thereto, and stirred at room temperature for an hour. The formed solid was filtered and the filtrate was washed with ethyl acetate (2×20 mL). The filtrate was dried at a reduced pressure to obtain a white solid target compound (0.90 g, 93%).1H NMR (600 MHz, CD3OD) delta 5.89 (m, 2H), 4.16 (m, 4H); LC-MS m/z 137.2 [M+1]+
The synthetic route of 63468-63-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; HANALL BIOPHARMA CO., LTD.; MIN, Chang Hee; KIM, Yong Eun; OH, Byung Kyu; LEE, Ji Sun; HEO, Hye Jin; OH, Ju Hoon; CHO, Woong; WO2014/123364; (2014); A1;,
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