With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.
General procedure: Synthetic routes of the target compound, pyrene-bisindolylmaleimide (PBM), are outlinedin Scheme 1. The synthesis of PBMstarted from dibromomaleimide (1), whichwas coupledwith two equivalents of 2-methylindole-MgBr and yielded bis-2-methylindolylmaleimide(BM) [10, 11]. Followed by the hydrolysis of 2 in KOH aqueous solution, bis-2-methylindolylmaleic acid anhydride was obtained with the nitrogen atom replaced byoxygen atom [12]. Subsequent imidization of bis-2-methyindolemaleic anhydride with1-aminopyrene yielded the target compound PBM. Bis-2-methylindolylmaleic acid anhydride (50 mg, 0.14 mmol) and 1-aminopyrene(35 mg, 0.16 mmol) dissolved in 2-methoxyethanol (25 mL). Three drops of triethylaminewas added to the solution. The mixture was heated to reflux for about 24 h. The reactionprocess was monitored by TLC. After the bis-2-methylindolylmaleic acid anhydride wasdisappeared. The reactionmixture was cool to ambient temperature and poured to water (25mL). The mixture was extracted with ethyl acetate (25 mL¡Á3). The collected organic phasewas dried over MgSO4. After filtration, the solvent was evaporated in vacuum. The crudeproduct was purified by silica gel column chromatography with ethyl acetate/petroleumether (1:2) as the eluant, affording dark red solid of PBM (61 mg, yield, 78%)., 1122-10-7
As the paragraph descriping shows that 1122-10-7 is playing an increasingly important role.
Reference£º
Article; Li, Xiaochuan; Son, Young-A; Molecular Crystals and Liquid Crystals; vol. 601; 1; (2014); p. 182 – 189;,
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