With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1334177-86-4,1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid,as a common compound, the synthetic route is as follows.
N-(3-Dimethylaminopropyl)-N’-ethylcarbodiimide (28 mg, 0.146 mmol, 1 eq) was added to a solution of 42 (203 mg, 0.146 mmol) and maleimide-PEGs acid (87 mg, 0.146 mmol) in chloroform (5 ml_). The reaction was stirred for 1 .5 h then diluted with chloroform (50 ml_), washed with water (50 ml_), brine (30 ml_), dried over magnesium sulphate, filtered and evaporated. Flash chromatography [gradient elution 100% DCM to 90% DCM/10% methanol] gave 43 as a pale yellow solid (205 mg, 72%). LC/MS, System 1 : RT 5.75 min; MS (ES+) m/z (relative intensity) 982.90 (100), 1963.70 (5)., 1334177-86-4
As the paragraph descriping shows that 1334177-86-4 is playing an increasingly important role.
Reference£º
Patent; SPIROGEN SARL; HOWARD, Philip, Wilson; EZEADI, Ebele; D’HOOGE, Francois; PATEL, Neki; KEMP, Gary; WO2015/52322; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem