With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.151038-94-7,6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide 2,2,2-trifluoroacetate,as a common compound, the synthetic route is as follows.
[4611] 10 mg (9.3 f.tmol) of N-(3-carboxypropyl)-N-methyl-L-valyl-N -[ (3R,4S,5S)-3-methoxy-l-{ (2S)-2-[ (lR,2R)-1-methoxy-2-methyl-3-oxo-3-{ [ (2R)-1-phenyl-4-( 4-sulphophenyl)butan-2-yl]amino }propyl]pyrrolidin-1-yl }-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide, 3.5 mg(10.3 flillOI) of 6-(2,5-dioxo-2,5-dihydro-lH-pyrrol-1-yl)hexanehydrazide trifluoroacetate, 4.3 mg (11.2 f.tmol) ofHATU and 4.9 fll (28 f.tmol) ofHlinig’s base were stirred in 1ml ofDMF at RT for 20 h. Subsequently, the reaction mixturewas purified by means of preparative HPLC. 4.2 mg (92%purity, 33% of theory) of the title compound were obtained.[4612] LC-MS (Method 1): R,=0.91 min; MS (ESipos):m/z=1166 (M+Ht
151038-94-7, The synthetic route of 151038-94-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SEATTLE GENETICS, INC.; LERCHEN, Hans-Georg; LINDEN, Lars; SHEIKH, Sherif El; WILLUDA, Joerg; KOPITZ, Charlotte C.; SCHUHMACHER, Joachim; GREVEN, Simone; MAHLERT, Christoph; STELTE-LUDWIG, Beatrix; GOLFIER, Sven; BEIER, Rudolf; HEISLER, Iring; HARRENGA, Axel; THIERAUCH, Karl-Heinz; BRUDER, Sandra; PETRUL, Heike; JOeRISSEN, Hannah; BORKOWSKI, Sandra; US2015/246136; (2015); A1;,
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