1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,1122-10-7
The 2,3-dibromomaleimide (2.55 g, 10.0 mmol) was placed in a 100 mL three-necked flask,Dissolved in 30 mL of dry DMF,Nitrogen protection, down to 0 C,Sodium hydride was added in two portions(480 mg, 12 mmol, 60% mass fraction in paraffin). After 1 h, 10 mL of dry DMF dissolved chloromethylbenzyl ether (2.08 mL, 15 mmol) was added,Rose to room temperature reaction 2h.After the drop to 0 C, adding 20 mL of saturated ammonium chloride solution to stop the reaction,Ethyl acetate, and the organic phase was dried over anhydrous sodium sulfate and concentrated.Column separation by petroleum column: Ethyl acetate = 50: 1 (v / v) eluting the compound4-benzyloxymethyl-2,3-dibromomaleimide 3.55 g, 94% yield.Magnesium wire (432 mg, 18.0 mmol) was placed in 100 mL dry three-necked flask,Add 4 mL of dry tetrahydrofuran, replace with argon,After the introduction of ethyl bromide (1.35 mL, 18.0 mmol)After reaction at room temperature for 15 min, the reaction was brought to 40 C for 30 min.The indole (2.11 g, 18.0 mmol) was introduced via a catheter for 1 h.Followed by the addition of N-benzyloxymethyl-2,3-dibromomaleimide (3.29 g, 8.9 mmol)Room temperature reaction 4h.The reaction was terminated by the addition of 20 mL of saturated ammonium chloride solution, extracted with ethyl acetate,The organic phase was dried over anhydrous sodium sulfate and concentrated. The column was separated by column chromatography,Petroleum ether: ethyl acetate = 4: 1 (v / v) to give 3.46 g of compound 185a in 94% yield.
1122-10-7 3,4-Dibromo-1H-pyrrole-2,5-dione 14279, apyrrolines compound, is more and more widely used in various fields.
Reference£º
Patent; Ocean University of China; Key Laboratory of Chemistry for Natural Products of Guizhou Province Chinese Academy of Sciences; Zhu, Weiming; Ma, Hongguang; Wang, Liping; Xu, Zhihong; Zhang, Yapeng; Wang, Yi; Liu, Peipei; (142 pag.)CN106083830; (2016); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem