Month: September 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2973-17-3,1-Allyl-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.

Synthesis Example f-III-6 Synthesis of Silicone Compound: 1 = n = 0, m =1 in the Chemical Structure 6 Drip 3.08 parts of the compound f-II: N-aryl maleimide, 10 parts of toluene, and 0.043 parts of xylene solution of 2 % by weight platinum / 1,3-divinyl-1,1,3,3-tetramethyl disiloxane complex (manufactured by Sigma-Aldrich Co.) to a solution of 5.0 parts of silicone compound: (1,1,1,3,5,5,5-heptamethyl trisiloxane (manufactured by Sigma-Aldrich Co) and 5.0 parts of toluene in about 60 minutes while stirring at a room temperature followed by reaction under the same condition one night. Thereafter, distill away the solvent with a reduced pressure, conduct stripping treatment for two hours with a reduced pressure of 10 mmHg at 40 C and confirm disappearance of absorption (2155 cm-1 of Si-H in infra-red absorption spectrum to obtain 5.01 parts of the target silicone compound f-M6. The infra-red absorption spectrum graph is shown as Fig. 8F., 2973-17-3

As the paragraph descriping shows that 2973-17-3 is playing an increasingly important role.

Reference£º
Patent; Ricoh Company, Ltd.; EP2520579; (2012); A2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3,4-dibromo-N-methyl ester maleimide was synthetized from the corresponding 3,4-dibromomaleimide by adapting the procedure disclosed by Castaeda et al. in Tetrahedron Lett. 2013, 54, 3493-3495.3,4-dibromomaleimide (5 g, 19.92 mmol) was dissolved in THE (175 ml). N-methylmorpholine (2.16 ml, 19.92 mmol) and methyl chloroformate (1.51 ml, 19.92 mmol) were added at room temperature under argon. The reaction mixture was stirred at room temperature under argon for 20 mm, then diluted with DCM (200 ml). The organic layer was washed with water (200 ml), dried over MgSO4, concentrated and lyophilized to yield 6.15 g (100%) of product.[00252] 1H NMR (500 MHz, CDCI3): 5= 4.01 (5, 3H). 130 NMR (126 MHz, CDCI3): 5= 159.23, 146.91, 131.41, 54.79., 1122-10-7

As the paragraph descriping shows that 1122-10-7 is playing an increasingly important role.

Reference£º
Patent; HEIDELBERG PHARMA RESEARCH GMBH; GALLO, Francesca; KORSAK, Barbara; MUELLER, Christoph; HECHLER, Thorsten; PAHL, Andreas; KULKE, Michael; SIMON, Werner; LUTZ, Christian; (163 pag.)WO2019/57964; (2019); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

2973-17-3, 1-Allyl-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis Example f-III-5 Synthesis of Silicone Compound: 1 = m = n = 0, and X1 = X3 = Substituent A-6 in the Chemical Structure 1 Drip 4.14 parts of the compound f-II: N-aryl maleimide, 10 parts of toluene, and 0.055 parts of xylene solution of 2 % by weight platinum / 1,3-divinyl-1,1,3,3-tetramethyl disiloxane complex (manufactured by Sigma-Aldrich Co.) to a solution of 3.0 parts of silicone compound: (1,1,3,3-tetramethyl trisiloxane (manufactured by Tokyo Chemical Industry Co., Ltd.) and 3.0 parts of toluene in about 60 minutes while stirring at a room temperature followed by reaction under the same condition one night. Thereafter, distill away the solvent with a reduced pressure, conduct stripping treatment for two hours with a reduced pressure of 10 mmHg at 40 C and confirm disappearance of absorption (2155 cm-1 of Si-H in infra-red absorption spectrum to obtain 4.14 parts of the target silicone compound f-M5. The infra-red absorption spectrum graph is shown as Fig. 8E., 2973-17-3

The synthetic route of 2973-17-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ricoh Company, Ltd.; EP2520579; (2012); A2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

134272-64-3, N-(2-Aminoethyl)maleimide Hydrochloride is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

NHS ester, compound 5a (8.2 mg, 7.6 muiotaetaomicron) and l-(2-aminoethyl)-lH-pyrrole-2,5-dione hydrochloride (2.2 mg, 0.011 mmol) were dissolved in anhydrous dichloromethane (305 mu) at room temperature. DIPEA (2.66 mu, 0.015mmol) was added and the reaction and was stirred for 3.5 hours. The reaction mixture was concentrated and was purified by RPHPLC (CI 8 column, CH3CN/H2O, gradient, 35% to 55%). The desired product fractions were frozen and lyophilized to give maleimide, compound D5 as a solid white powder (5.3 mg, 58% yield). LCMS = 5.11 min (8 min method). MS (m/z): 1100.6 (M + 1)+.

134272-64-3, As the paragraph descriping shows that 134272-64-3 is playing an increasingly important role.

Reference£º
Patent; IMMUNOGEN, INC.; KOVTUN, Yelena; TAVARES, Daniel; RUI, Lingyun; CHITTENDEN, Thomas; (386 pag.)WO2017/4026; (2017); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To 2.5 g of 3,4-dibromo-1H-pyffole-2,5-dione (10 mmol) and 1 g of NMM in 60 mL of THF, MeOCOC1 (10 mmol, 940 mg in 10 ml DCM) was added dropwise, stuffed for 20 mm, then the reaction solution was diluted with 6o mL of DCM, washed 3 time by water, the organic phase was stirred by sodium sulfate anhydrous, concentrated, 2.65g of methyl 3,4-dibromo-2,5-dioxo-2H-pyrrole-1(5H)-carboxylate was obtained. To 311mg, 1 mmol of this compound, 2-(2-azidoethoxy)ethanamine (130 mg, 1 mmol) and 5 mL DCM was added, TLC shown the reaction finished in 20 mm, then extracted by DCM and brine, washed by NH4C1 solution, dried on sodium sulfate anhydrous, and then concentrated for column purification, flashed by 2:1 hexane and ethyl ethylate, 230 mg of 1-(2-(2-azidoethoxy)ethyl)-3,4-dibromo-1H-pyffole-2,5-dione obtained. 1HNMR: 3.32 ppm (t, J = 5.0 Hz, 1H), 3.40 ppm (t, J = 5.0Hz, 1H), 3.50 ppm (q, J =5.0 Hz, 1H), 3.62 ppm (t, J = 5.0 Hz, 1H), 3.63-3.69 ppm (m, 3H),3.84 ppm (t, J = 5 hz, 1H). Fw: 365.9, C8H8Br2N4O3 Mass Peaks (1:2:1): 366.9, 368.9,370.9.

1122-10-7, The synthetic route of 1122-10-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SORRENTO THERAPEUTICS, INC.; FU, Yanwen; KAUFMANN, Gunnar, F.; JONES, Bryan; TOUGHIRI, Raheleh; (82 pag.)WO2015/175357; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

25021-08-3, 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Trifluoroacetic Acid/N-(2-aminoethyl)-2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetamide (1:1) The title compound was prepared by classical methods of peptide chemistry from commercially available (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid and tert-butyl (2-aminoethyl)carbamate.

25021-08-3, As the paragraph descriping shows that 25021-08-3 is playing an increasingly important role.

Reference£º
Patent; Bayer Pharma Aktiengesellschaft; LERCHEN, Hans-Georg; REBSTOCK, Anne-Sophie; CANCHO GRANDE, Yolanda; MARX, Leo; STELTE-LUDWIG, Beatrix; TERJUNG, Carsten; MAHLERT, Christoph; GREVEN, Simone; SOMMER, Anette; BERNDT, Sandra; (684 pag.)US2018/169256; (2018); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.151038-94-7,6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide 2,2,2-trifluoroacetate,as a common compound, the synthetic route is as follows.

[4611] 10 mg (9.3 f.tmol) of N-(3-carboxypropyl)-N-methyl-L-valyl-N -[ (3R,4S,5S)-3-methoxy-l-{ (2S)-2-[ (lR,2R)-1-methoxy-2-methyl-3-oxo-3-{ [ (2R)-1-phenyl-4-( 4-sulphophenyl)butan-2-yl]amino }propyl]pyrrolidin-1-yl }-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide, 3.5 mg(10.3 flillOI) of 6-(2,5-dioxo-2,5-dihydro-lH-pyrrol-1-yl)hexanehydrazide trifluoroacetate, 4.3 mg (11.2 f.tmol) ofHATU and 4.9 fll (28 f.tmol) ofHlinig’s base were stirred in 1ml ofDMF at RT for 20 h. Subsequently, the reaction mixturewas purified by means of preparative HPLC. 4.2 mg (92%purity, 33% of theory) of the title compound were obtained.[4612] LC-MS (Method 1): R,=0.91 min; MS (ESipos):m/z=1166 (M+Ht

151038-94-7, The synthetic route of 151038-94-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SEATTLE GENETICS, INC.; LERCHEN, Hans-Georg; LINDEN, Lars; SHEIKH, Sherif El; WILLUDA, Joerg; KOPITZ, Charlotte C.; SCHUHMACHER, Joachim; GREVEN, Simone; MAHLERT, Christoph; STELTE-LUDWIG, Beatrix; GOLFIER, Sven; BEIER, Rudolf; HEISLER, Iring; HARRENGA, Axel; THIERAUCH, Karl-Heinz; BRUDER, Sandra; PETRUL, Heike; JOeRISSEN, Hannah; BORKOWSKI, Sandra; US2015/246136; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1334177-86-4,1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid,as a common compound, the synthetic route is as follows.

Piperidine (0.2 mL) was added to a solution of 90 (77 mg, 63.4 mumomicronIota) in DMF (1 mL). The reaction mixture was allowed to stir for 20 minutes. The reaction mixture was carefully diluted with DCM (50 mL) and washed with water (50 mL). The organic layers was washed with brine (100 mL), dried over MgSO4, filtered and evaporated under reduced pressure to provide the unprotected valine intermediate. The crude residue was immediately redissolved in chloroform (5 mL). Mal(Peg)8-acid (56 mg, 95 mumomicronIota) and EDCI (18 mg, 95 mumomicronIota) were added, followed by methanol (0.1 mL). The reaction was allowed to stir for 3 hours at room temperature at which point completion was observed by TLC and LC/MS (1 .19 min (ES+) m/z (relative intensity) 784.25 (([M + 2H] 2+)/2, 100)). The reaction mixture was diluted with chloroform (50 mL), washed with water (100 mL), dried (MgS04), filtered and evaporated in vacuo, followed by high vacuum drying, to provide the crude product. Purification by flash chromatography (gradient elution: HPLC grade 96:4 v/v CHCl3/MeOH to 90:10 v/v CHCl3/MeOH) gave 91 as a yellow solid (43 mg, 43%). 1H NMR (400 MHz, CDCI3) delta 8.73 (s, 1 H), 7.88 (dd, J = 7.6, 3.9 Hz, 2H), 7.75 (d, J = 8.6 Hz, 2H), 7.52 (d, J = 2.0 Hz, 2H), 7.44 (s, 1 H), 7.40 – 7.28 (m, 4H), 6.91 (d, J = 8.8 Hz, 2H), 6.81 (s, 2H), 6.69 (s, 2H), 6.48 (s, 1 H), 4.72 – 4.63 (m, 1 H), 4.46 – 4.34 (m, 2H), 4.25 – 4.03 (m, 6H), 3.95 (s, 4H), 3.84 (dd, J = 17.2, 10.1 Hz, 4H), 3.72 – 3.46 (m, 30H), 3.44 – 3.32 (m, 4H), 3.30 – 3.20 (m, 4H), 2.75 – 2.63 (m, 1 H), 2.59 (s, 4H), 2.55 – 2.43 (m, 3H), 2.37 (s, 3H), 2.29 (dd, J = 12.7, 6.7 Hz, 1 H), 2.03 – 1 .89 (m, 4H), 1 .72 (d, J = 22.7 Hz, 8H), 1 .46 (d, J = 7.2 Hz, 3H), 1 .01 (dd, J = 1 1 .5, 6.9 Hz, 6H). MS (ES+) m/z (relative intensity) 784.25 (([M + 2H] 2+)/2, 100)., 1334177-86-4

The synthetic route of 1334177-86-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VAN BERKEL, Patricius Hendrikus Cornelis; HOWARD, Philip Wilson; (283 pag.)WO2016/166298; (2016); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

25021-08-3, 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N-[(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetyl]-L-valyl-N-{3-[{(1R)-1-[1-benzyl-4-(2,5-difluorophenyl)-1H-pyrrol-2-yl]-2,2-dimethylpropyl}(glycoloyl)amino]propyl}-L-alaninamide The title compound was prepared from Example M9 first by coupling with N-[(benzyloxy)carbonyl]-L-valyl-L-alanine in the presence of HATU and N,N-diisopropylethylamine. In the next step, the Z protective group was removed by hydrogenating for 1 hour over 10% palladium on activated carbon at RT under hydrogen standard pressure and then converting the deprotected intermediate into the title compound by coupling with (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid in the presence of HATU and N,N-diisopropylethylamine. LC-MS (Method 1): Rt=1.21 min; MS (ESIpos): m/z=777 (M+H)+., 25021-08-3

25021-08-3 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid 319935, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; Bayer Pharma Aktiengesellschaft; LERCHEN, Hans-Georg; REBSTOCK, Anne-Sophie; CANCHO GRANDE, Yolanda; MARX, Leo; STELTE-LUDWIG, Beatrix; TERJUNG, Carsten; MAHLERT, Christoph; GREVEN, Simone; SOMMER, Anette; BERNDT, Sandra; (684 pag.)US2018/169256; (2018); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

134272-64-3, N-(2-Aminoethyl)maleimide Hydrochloride is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

134272-64-3, To a solution of 1-(2-aminoethyl)-1H-pyrrol-2,5-dione 2,2,2-hydrochloride: (150mg, 0.849mmol) and TEA (350muL, 2.50mmol) in THF (4mL) was added (E)-perfluorophenyl 4-(phenyldiazenyl)benzoat 7 (666mg, 1.70mmol) in THF (4mL) dropwise. After 16h at rt, the solvent was evaporated, the resulting residue was dissolved in CHCl3 and washed with H2O (30mL), 1M HCl (30mL) and brine (30mL). The organic layer was dried over Na2SO4, filtered and concentrated. The crude product was purified by silica column (eluent EtOAc:hexane: 1:4?1:1; Rf:0.10?0.50) to yield the product as an orange solid (243mg; 82%). 1H NMR (500MHz, DMSO) delta 8.73 (t, J=6.0Hz, 1H), 7.96-7.88 (m, 6H), 7.67-7.56 (m, 3H), 7.01 (s, 2H), 3.62 (t, J=5.7Hz, 2H), 3.45 (dd, J=11.6, 5.9Hz, 2H); 13C NMR (126MHz, DMSO) delta 171.04, 165.76, 153.24, 151.89, 136.61, 134.51, 131.92, 129.49, 128.35, 122.67, 122.27, 37.71, 37.10; HPLC/MS (tr=13.92min; ESI) found: 349.1 (M+H)+, calc.: 349.1.

134272-64-3 N-(2-Aminoethyl)maleimide Hydrochloride 22118207, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Article; Horstmann, Benjamin; Korbus, Michael; Friedmann, Tatjana; Wolff, Christiane; Thiele, Christina Marie; Meyer-Almes, Franz-Josef; Bioorganic Chemistry; vol. 57; (2014); p. 155 – 161;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem