Month: September 2020

73286-71-2,73286-71-2, N-Boc-2-pyrroline is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Example 1; tert-Butyl (3aR*,9bR*)-2,3,3a,4,5,5a,9a,9b-octahydro-lH- pyrrolo[3,2-c]quinoline-1-carboxylate; Sodium (1.2 g, 50 mmol) was dissolved in methanol (15 ml), aniline (0.9 g, 10 mmol) was added at room temperature, and the mixture was stirred for 10 min. This mixture was added to a suspension of paraformaldehyde (0.42 g, 14 mmol) in methanol (10 ml), and the mixture was stirred at room temperature for 5 hrs. The reaction mixture was poured into ice water, and the mixture was extracted with diethyl ether. The extract was dried (over anhydrous MgS04), and the solvent was evaporated under reduced pressure. The residue was dissolved in methanol (20 ml), tert-butyl 2,3-dihydro- 1H-pyrrole-1-carboxylate (850 mg, 5 mmol) was added and the mixture was heated under reflux for 18 hrs. The residue was subjected to column chromatography using silica gel (30 g) and eluted with hexane-ethyl acetate (9: 1-4:1, v/v) to give the title compound (180 mg, 12%) as an amorphous form. ?H-NMR (CDC13) 8: 1 . 48 (9H, d, J=6.1 Hz) , 1 . 76-2 . 01 (2H, m), 2.23-2.45 (lH, m), 3.13-3.57 (5H, m), 5.09 (lH, dd, J=47.2,4.0 Hz), 6.54-6.85 (2H, m), 7.10-7.23 (2H, m). LC/MS (ESI) m/z: 275 (MH+).

73286-71-2 N-Boc-2-pyrroline 10844857, apyrrolines compound, is more and more widely used in various.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2005/105802; (2005); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.25021-08-3,2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid,as a common compound, the synthetic route is as follows.

N-[(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetyl]-L-valyl-N-{3-[{(1R)-1-[1-benzyl-4-(2,5-difluorophenyl)-1H-pyrrol-2-yl]-2,2-dimethylpropyl}(glycoloyl)amino]propyl}-L-alaninamide The title compound was prepared from Example M9 first by coupling with N-[(benzyloxy)carbonyl]-L-valyl-L-alanine in the presence of HATU and N,N-diisopropylethylamine. In the next step, the Z protective group was removed by hydrogenating for 1 hour over 10% palladium on activated carbon at RT under hydrogen standard pressure and then converting the deprotected intermediate into the title compound by coupling with (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid in the presence of HATU and N,N-diisopropylethylamine. LC-MS (Method 1): Rt=1.21 min; MS (ESIpos): m/z=777 (M+H)+.

25021-08-3, As the paragraph descriping shows that 25021-08-3 is playing an increasingly important role.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; LERCHEN, Hans-Georg; REBSTOCK, Anne-Sophie; CANCHO GRANDE, Yolanda; WITTROCK, Sven; BERNDT, Sandra; GRITZAN, Uwe; FITTING, Jenny; STELTE-LUDWIG, Beatrix; JONES, Patrick; MAHLERT, Christoph; VOTSMEIER, Christian; SCHOeNFELD, Dorian; TRAUTWEIN, Mark; WEBER, Ernst; PAWLOWSKI, Nikolaus; GREVEN, Simone; GLUeCK, Julian Marius; HAMMER, Stefanie; DIETZ, Lisa; MAeRSCH, Stephan; (357 pag.)US2020/138970; (2020); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.

1122-10-7, General procedure: In a 100 mL dry one-neck round bottom flask equipped with a magnetic stir bar, 3,4-dibromomaleimide (1.00 equiv) was added under N2 atmosphere. Acetone (0.62 M) and K2CO3 (1.10 equiv) were successively added and vigorously stirred for 10 min. Then, the corresponding alkylating reagent (1.20-1.40 equiv) was added to one portion. The reaction was stirred during the overnight period and quenched by solvent evaporation and extraction with AcOEt (3 x 20 mL). The crude sample from the reaction was purified by column chromatography. The spectroscopic data match perfectly with those previously described.

As the paragraph descriping shows that 1122-10-7 is playing an increasingly important role.

Reference£º
Article; Mendoza-Macias, Claudia Leticia; Solorio-Alvarado, Cesar Rogelio; Alonso-Castro, Angel Josabad; Alba-Betancourt, Clara; Deveze-Alvarez, Martha Alicia; Padilla-Vaca, Felipe; Reyes-Gualito, Arturo; Chemical Papers; vol. 74; 5; (2020); p. 1429 – 1438;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

541-59-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.541-59-3,Maleimide,as a common compound, the synthetic route is as follows.

Example 1 N-(Methoxycarbonyl)maleimide (Compound 1) Methylchloroformate (4.4 mL, 56.7 mmol, 1 eq) was added to a solution of maleimide (5.5 g, 56.7 mmol, 1 eq) and NMM (6.2 mL, 56.7 mmol, 1 eq) in 200 mL of EtOAc at 0 C. The suspension was stirred at 0 C. for 30 minutes, filtered and washed with EtOAc. Filtrate and washings were combined and washed with cold water and dried over anhydrous Na2SO4. After filtration and evaporation under vacuum a pink solid was obtained. Purification by column chromatography on silica gel (Hexane-EtOAc, 1:1, v/v) provided the product (4.8 g, 55%).

The synthetic route of 541-59-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ENZON PHARMACEUTICALS, INC.; US2010/233190; (2010); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1334177-86-4, 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Procedure: Bromine (0.20 ml, 3.88 mmol) was added to a solution of 1 – (2,5-dioxo-2,5-dihydro-1 H-pyrrol-1 -yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4- azahentriacontan-31 -oic acid (1000 mg, 1 .69 mmol) in methylene chloride (17 ml). After stirring for 14 h, the solution was cooled to -10C in an ice/brine bath and diisopropylethylamine (1 .5 ml, 8.61 mmol) was slowly added dropwise. After stirring for an additional 24 h, during which time the solution warmed to ambient temperature, the solution was concentrated under reduced pressure to afford crude 1 -(3-bromo- 2,5-dioxo-2,5-dihydro-1 H-pyrrol-1 -yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4- azahentriacontan-31 -oic acid. UPLC/MS 1 .18 min (5-95% acetonitrile/water + 0.1 % formic acid over 2 min, hold at 95% for 0.5 min, then 95-5% over 0.1 min, and hold at 5% for 0.4 min. Column used was Waters BEH C18 1 .7 muiotatauiota, 2.1 x 50 mm, flow rate was 0.8 mL/min.), m/z 671 .6 and 673.6 [M+H]+.

1334177-86-4, 1334177-86-4 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid 51340955, apyrrolines compound, is more and more widely used in various.

Reference£º
Patent; IGENICA BIOTHERAPEUTICS, INC.; JACKSON, David, Y.; HA, Edward; SAUER, Paul; BOWERS, Simeon; BRUHNS, Maureen, Fitch; MONTEON, Jorge; BEHRENS, Christopher; HALCOMB, Randall, L.; (281 pag.)WO2016/64749; (2016); A2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.134272-64-3,N-(2-Aminoethyl)maleimide Hydrochloride,as a common compound, the synthetic route is as follows.

(0432) NHS ester 1a (8.2 mg, 7.6 mumol) (prepared according to procedures described in US 2016/0082114, incorporated herein by reference) and 1-(2-aminoethyl)-1H-pyrrole-2,5-dione hydrochloride (2.2 mg, 0.011 mmol) were dissolved in anhydrous dichloromethane (305 muL) at room temperature. DIPEA (2.66 muL, 0.015 mmol) was added and the reaction and was stirred for 3.5 hours. The reaction mixture was concentrated and was purified by RPHPLC (C18 column, CH3CN/H2O, gradient, 35% to 55%). The desired product fractions were frozen and lyophilized to give maleimide, compound D1 as a solid white powder (5.3 mg, 58% yield). LCMS=5.11 min (8 min method). MS (m/z): 1100.6 (M+1)+.

134272-64-3, As the paragraph descriping shows that 134272-64-3 is playing an increasingly important role.

Reference£º
Patent; IMMUNOGEN, INC.; Hilderbrand, Scott A.; Hutchins, Benjamin M.; (94 pag.)US2018/208562; (2018); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6913-92-4,1-Benzyl-3-pyrroline,as a common compound, the synthetic route is as follows.

6913-92-4, To an ice-cooled solution of 1-benzyl pyrroline (0. 01 mol), 98% H2SO4 (0.012 mol), water (1.5 g), and acetone (10 mL) in a round bottom flask was added 77% m- CPBA (0. 013 mol) with stirring, and allowed to react for about 50 h at room temperature. After completion of the reaction (TLC monitor), acetone was evaporated under reduced pressure, and the mixture was neutralized by 1M NAOH, and extracted with toluene (30 mL X3). The precipitates that appeared were filtered, and the filtrate was repeatedly washed with water (30 mL x2). After the solvent was evaporated under reduced pressure, pure product was obtained in 77% yield via column chromatography (silica gel, CH2CL2 : EtOAc: MeOH, 7.5 : 2.00 : 0.5).

6913-92-4 1-Benzyl-3-pyrroline 561506, apyrrolines compound, is more and more widely used in various.

Reference£º
Patent; NORTHWESTERN UNIVERSITY; WO2005/26111; (2005); A2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6913-92-4,1-Benzyl-3-pyrroline,as a common compound, the synthetic route is as follows.

6913-92-4, A mixture of 0.675 g (3.14 mMol) 7-bromo-5-fluorobenzofuran, 5.0 g (31.40 mMol)1-benzyl-3-pyrroline, 2.19 mL (12.56 mMol), N,N-diisopropylethylamine, 0.399 g (9.42 mMol) LiCl, 0.154 g (0.66 mMol) tri-2-furylphosphine, and 0.070 g (0.314 mMol) palladium diacetate in 10 mL N,N-dimethylformamide was heated under nitrogen at 100C for 48 hours. The mixture was diluted with 10 mL diethyl ether and filtered through celite. The filtrate was concentrated under reduced pressure and the oily residue was submitted to kugelrohr distillation to remove most of the pyrrole and pyrrolidine side-products. Flash chromatography of the residue (Et3N/Et2O/hexane 1:39:60) yielded 1-benzyl-3-(5-fluorobenzofur-7-yl)pyrrolidine (173 mg, 19%) as a colorless oil. HRMS calculated for C19H19FNO: 296.1450; found: 296.1437

The synthetic route of 6913-92-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ELI LILLY AND COMPANY; EP1204659; (2003); B1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.766-36-9,3-Ethyl-4-methyl-2,5-dihydro-1H-pyrrol-2-one,as a common compound, the synthetic route is as follows.

766-36-9, In a 500 mL round bottom flask, diethyl pyrrole aldehyde 5 (2.53 g, 9.04 mmol) and 3-ethyl-4-methyl-1H-pyrrol-2-one (1.12 g, 9.04 mmol) were dissolved in 4 M KOH (100 mL) and methanol (25 mL). The reaction mixture was heated at reflux for 4 h, then stirred overnight at room temperature. The solution was chilled in an ice bath and acidified with HCl (conc.) until red on pH paper. The resulting precipitate was collected by vacuum filtration, washed with water, and dried. The crude product was recrystallized from methylene chloride and hexanes to afford pure product (2.71 g, 7.54 mmol, 83percent). Mp 213?216 ¡ãC; 1H NMR (400 MHz, CDCl3, 30 ¡ãC): delta (ppm) 14.40 (s, 1H), 11.76 (s, 1H), 10.19 (s, 1H), 5.98 (s, 1H), 3.63 (q, J=6.9 Hz, 2H), 3.26 (q, J=6.9 Hz, 2H), 2.39 (q, J=7.5 Hz, 5H), 2.08 (s, 1H), 1.29 (t, J=7.5 Hz, 3H), 1.13 (t, J=7.8 Hz, 3H), 1.06 (t, J=6.9 Hz, 3H); 13C NMR (100 MHz, CDCl3, 30 ¡ãC): delta (ppm) 175.8, 166.0, 142.3, 134.7, 133.1, 127.9, 127.1, 123.4, 98.5, 43.1, 39.0, 16.7, 14.3, 13.2, 13.1, 11.5, 9.52; IR (KBr) (cm?1): 1129.3, 1178.8, 1278, 1506, 1654.8, 1724.2, 2879.5, 2939, 2963.8, 3063, 3097.6, 3236.5, 3500; MS (EI+) 243, 269, 287, 315, 359 m/z; HRMS (ESI+) C19H25N3O4 calcd: 359.1845 amu; found: 359.1854 amu.

766-36-9 3-Ethyl-4-methyl-2,5-dihydro-1H-pyrrol-2-one 854146, apyrrolines compound, is more and more widely used in various.

Reference£º
Article; Jarvis, Tia; Saint-Louis, Carl Jacky; Fisch, Alexander R.; Barnes, Korry L.; Dean, Dolan; Flores, Luis A.; Hunt, Thomas F.; Munro, Lyndsay; Simmons, Tyler J.; Catalano, Vincent J.; Zhu, Lei; Schrock, Alan K.; Huggins, Michael T.; Tetrahedron; vol. 74; 14; (2018); p. 1698 – 1704;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1334177-86-4, 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1334177-86-4, N-(3-Dimethylaminopropyl)-N?-ethylcarbodiimide (28 mg, 0.146 mmol, 1 eq) was added to a solution of 105 (203 mg, 0.146 mmol) and maleimide-PEG8 acid (87 mg, 0.146 mmol) in chloroform (5 mL). The reaction was stirred for 1 .5 h then diluted with chloroform (50 mL), washed with water (50 mL), brine (30 mL), dried over magnesium sulphate, filtered and evaporated. Flash chromatography [gradient elution 100% DCM to 90% DCM/i0% methanol] gave 106 as a pale yellow solid (205 mg, 72%). LC/MS: RT 5.75 mm; MS (ES+) m/z (relative intensity) 982.90 (100), 1963.70 (5).

1334177-86-4 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid 51340955, apyrrolines compound, is more and more widely used in various.

Reference£º
Patent; VAN BERKEL, Patricius Hendrikus Cornelis; HOWARD, Philip Wilson; (290 pag.)WO2016/166299; (2016); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem