Month: September 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.134272-64-3,N-(2-Aminoethyl)maleimide Hydrochloride,as a common compound, the synthetic route is as follows.

(SPDB-Ala-Gly-Gly)2-Lys-P-Ala-ONHS (22 mg, 0.020 mmol) was dissolved in anhydrous dimethyl formamide (400 mu) to which was added DM4 (30 mg, 0.038) with magnetic stirring. After 2 min deionized water (20 mu) was added then after 15 min diisopropylethyl amine (10 mu, mmol) and H2N-(CH2)2-Mal HC1 salt (3.7 mg, 0.022 mmol) were added. After an additional 30 min, sample was injected directly onto a 19 mm x 150 mm C18 HPLC column eluting with deionized water containing 0.2% formic acid with a 5-95% linear acetonitrile gradient. Flow rate was 20 mL/min. Fractions containing pure desired product were combined and frozen then lyophilized to give 19 mg (38% yield) of product as a white solid. MS [M + Na]+ calcd.2491.0; found 2491.3., 134272-64-3

The synthetic route of 134272-64-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; IMMUNOGEN, INC.; WIDDISON, Wayne, C.; CHARI, Ravi, V.J.; WO2014/194030; (2014); A2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

6913-92-4, 1-Benzyl-3-pyrroline is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6913-92-4, 6.01.28.02 Benzyl-2,5-dihydro-1H-pyrrole-1-carboxylate 43 mL benzyloxycarbonyl chloride in 135 mL dichlormethane was added to 17.6 g 1-benzyl-2,5-dihydro-1H-pyrrole in 135 mL dichlormethane at 0 C. in 60 min. The mixture was stirred 3 h at RT and washed with saturated sodium hydrogencarbonate solution. The organic layer was dried and evaporated. The residue was purified by chromatography on silica gel (hexane/ethyl acetate: 5/1) to give 19.7 g of the desired product. Rt: 16.50 min. (method AG)

As the paragraph descriping shows that 6913-92-4 is playing an increasingly important role.

Reference£º
Patent; GRAUERT, Matthias; BISCHOFF, Daniel; DAHMANN, Georg; KUELZER, Raimund; RUDOLF, Klaus; WELLENZOHN, Bernd; US2013/143870; (2013); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1334177-86-4, 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,1334177-86-4

(e) N-((S)- 1-(((S)- 1-((4-((S)-8-(3-(((S) -2-(Benzo[d][1, 3]dioxol-5-yI) – 7-methoxy-5-oxo-5, 1 ladihydro- 1H-pyrrolo[2, 1-c][1, 4]benzodiazepin-8-yI) oxy) propoxy)- 7-methoxy-5-oxo-5, 1 ladihydro- 1H-pyrrolo[2, 1-c][1, 4]benzodiazepin-2-yI)phenyl)amino)- 1-oxopropan-2-yI)amino)-3- methyl- 1-oxobutan-2-yl)- 1-(3-(2, 5-dioxo-2, 5-dihydro- 1H-pyrrol- 1-yl)propanamido)- 3,6,9, 12,15, 18,21, 24-octaoxaheptacosan-2 7-amide (33)The imine 32 (92 mg, 0.1 mmol, 1.1 equiv.) was dissolved in CHCI3 (6 mL) with one drop of anhydrous MeOH to aid dissolution. Maleimide-PEG8-acid (53 mg, 0.09 mmol, 1 equiv.) was added followed by EEDQ (33 mg, 0.14 mmol, 1.5 equiv.). This was left to stir vigorously at room temperature under Ar for 4 days until LC/MS analysis showed majority product formation. The solvent was removed in vacuo and the crude product was partially purified by silica gel column chromatography (CHCI3 with 1% to 10% MeOH gradient) yielding 33 (81mg). The material was purified further by preparative HPLC to give 33 as a yellow solid (26.3 mg, 18%). Fast Formic run: LC/MS (1.39 mm (ES+) mlz (relative intensity) 1485.00 ([M + H]+., 64).

1334177-86-4 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid 51340955, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; VAN BERKEL, Patricius Henrikus Cornelis; HOWARD, Philip Wilson; WILLIAMS, David G; WO2015/159076; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

151038-94-7, 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide 2,2,2-trifluoroacetate is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Acetoxycisplatin(4-acetylphenyl)carbamate (215 mg, 0.400 mmol, 1 .0 equiv) was dissolved in DMF (0.05M, 8 mL) and treated with 6-(2,5-dioxo-2,5-dihydro-1 H- pyrrol-1 -yl)hexanehydrazide TFA salt (163 mg, 0.480 mmol, 1 .2 equiv) at room temprature. The reaction mixture was stirred at room temperature overnight. Dichloromethane was added to the reaction mixture and the suspension was filtered to provide a yellow solid (230mg, 77% yield, 90.9% pure). The residue obtained was triturated with MeCN to provide compound 18 as a yellow solid (144 mg, 48% yield, 97.3% pure). 1H NMR (500 MHz, DMF-d7) delta 10.28 (s, 0.4H), 10.15 (s, 0.6H), 9.74 (brs, 1 H), 7.79-7.72 (m, 2H), 7.61 -7.54 (m, 2H), 7.22-6.81 (m, 6H), 7.02 (s, 2H), 3.50-3.44 (m, 2H), 2.74-2.70 (m, 1 .2H), 2.40-2.35 ( m, 0.8H), 2.33 (s, 2H), 2.29 (s, 1 H), 1 .93 (s, 3H), 1 .72-1 .63 (m, 2H), 1 .62-1 .53 (m, 2H), 1 .42-1 .29 (m, 2H); HPLC-MS 97%, m/z for CziHsoC NeOyPt [(M+H)+] = 745.2., 151038-94-7

As the paragraph descriping shows that 151038-94-7 is playing an increasingly important role.

Reference£º
Patent; BLEND THERAPEUTICS, INC.; MOREAU, Benoit; BILODEAU, Mark T.; WHALEN, Kerry; MEETZE, Kristan; SINGH, Sukhjeet; WOOSTER, Richard; LEMELIN, Charles-Andre; (139 pag.)WO2015/200250; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

25021-08-3, 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of Example 2.160.3 (557.5 mg), 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid (272 mg) and O-(7-azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (667 mg) in N, N-dimethylformamide (1.75 mL) at 0 C. was added N,N-diisopropylethylamine (0.459 mL). The resulting mixture was stirred at 0 C. for 1 hour. The reaction mixture was mixed with saturated aqueous NH4Cl mixture, extracted with ethyl acetate and washed with brine. The organic layer was dried over sodium sulfate, filtered and concentrated. The residue was purified by silica gel column chromatography, eluting with petroleum ether/ethyl acetate (2/1), to provide the title compound. MS (LC-MS) m/e 795.3 (M+Na)+.

25021-08-3, The synthetic route of 25021-08-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AbbVie Inc.; Benatuil, Lorenzo; Bruncko, Milan; Chao, Debra; Izeradjene, Kamel; Judd, Andrew S.; Phillips, Andrew C.; Souers, Andrew J.; Thakur, Archana; (556 pag.)US2017/355769; (2017); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of maleimide (2.0 g, 20.6 minol) in CHCI3 (20 mL) was added a solution of Br2(1.1 mL, 21.33 minol) in CHCI3 (15 mL). The mixture was heated to reflux for 2 h and thencooled to rt. The precipitate formed was collected by Buchner filtration (Whatman number5 paper) and washed with cold CHCI3 (2 x 50 mL) to afford the crude dibromo-maleimide asa pale yellow powder that was used without further purification. Crude dibromo-maleimidewas dissolved in anhydrous THF (50 mL) and cooled to 0 C. A solution of anhydrous NEt3(2.9 mL) in anhydrous THF (10 mL) was then added over 5 mins and the resulting pale pinksuspension stirred at 0 C for 2 h. Without warming, the suspension was filtered and thefiltrate concentrated in vacuo to afford the title compound 24 (2.30 g, 63%) as a light yellow solid. 1H NMR (400 MHz, CDCI3) oe 6.89 (1H, s, 5-H), 7.68 (1H, br s, 2-H); 13C NMR (100 MHz, CDCI3) oe 132.2, 132.8, 164.8, 167.8. The 1H and 13C NMR data obtained was in agreement with that reported from literature.20

1122-10-7, 1122-10-7 3,4-Dibromo-1H-pyrrole-2,5-dione 14279, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; SAMMUT, Ivan Andrew; HARRISON, Joanne Clare; HEWITT, Russell James; READ, Morgayn Iona; STANLEY, Nathan John; WOODS, Laura Molly; KUEH, Jui Thiang Brian; JAY-SMITH, Morgan; SMITH, Robin Andrew James; GILES, Gregory; LARSEN, Lesley; RENNISON, David; BRIMBLE, Margaret Anne; LARSEN, David Samuel; (209 pag.)WO2017/95237; (2017); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1334177-86-4,1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid,as a common compound, the synthetic route is as follows.

N-(3-Dimethylaminopropyl)-N’-ethylcarbodiimide (28 mg, 0.146 mmol, 1 eq) was added to a solution of 42 (203 mg, 0.146 mmol) and maleimide-PEGs acid (87 mg, 0.146 mmol) in chloroform (5 ml_). The reaction was stirred for 1 .5 h then diluted with chloroform (50 ml_), washed with water (50 ml_), brine (30 ml_), dried over magnesium sulphate, filtered and evaporated. Flash chromatography [gradient elution 100% DCM to 90% DCM/10% methanol] gave 43 as a pale yellow solid (205 mg, 72%). LC/MS, System 1 : RT 5.75 min; MS (ES+) m/z (relative intensity) 982.90 (100), 1963.70 (5)., 1334177-86-4

As the paragraph descriping shows that 1334177-86-4 is playing an increasingly important role.

Reference£º
Patent; SPIROGEN SARL; HOWARD, Philip, Wilson; EZEADI, Ebele; D’HOOGE, Francois; PATEL, Neki; KEMP, Gary; WO2015/52322; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1334177-86-4,1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid,as a common compound, the synthetic route is as follows.

N-(3-Dimethylaminopropyl)-N’-ethylcarbodiimide (28 mg, 0.146 mmol, 1 eq) was added to a solution of 105 (203 mg, 0.146 mmol) and maleimide-PEG8 acid (87 mg, 0.146 mmol) in chloroform (5 mL). The reaction was stirred for 1 .5 h then diluted with chloroform (50 mL), washed with water (50 mL), brine (30 mL), dried over magnesium sulphate, filtered and evaporated. Flash chromatography [gradient elution 100% DCM to 90% DCM/10% methanol] gave 106 as a pale yellow solid (205 mg, 72%). LC/MS: RT 5.75 min; MS (ES+) m/z (relative intensity) 982.90 (100), 1963.70 (5)., 1334177-86-4

The synthetic route of 1334177-86-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VAN BERKEL, Patricius Hendrikus Cornelis; HOWARD, Philip Wilson; (308 pag.)WO2016/166304; (2016); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred solution of 2,3-dibromomaleimide23 (1.0 mmol) in CH2Cl2 (20ml) Et3N (2.0mmol) and thiol (2.1mmol) were added under argon atmosphere and stirred for 3 h at room temperature. The reaction mixture was evaporated,and the crude product was purified by flash chromatography to give the desired compound.

1122-10-7, As the paragraph descriping shows that 1122-10-7 is playing an increasingly important role.

Reference£º
Article; Csavas, Magdolna; Miskovics, Adrienn; Szcs, Zsolt; Rth, Erzsebet; Nagy, Zsolt L; Bereczki, Ilona; Herczeg, Mihaly; Batta, Gyula; Nemes-Nikodem, Eva; Ostorhazi, Eszter; Rozgonyi, Ferenc; Borbas, Aniko; Herczegh, Pal; Journal of Antibiotics; vol. 68; 9; (2015); p. 579 – 585;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7544-75-4,3,4-Dihydro-2H-pyrrol-5-amine hydrochloride,as a common compound, the synthetic route is as follows.

7544-75-4, 1) 7,8-Dihydro-2H,6H-pyrrolo[1,2-a]-1,3,5-triazine-2,4(3H)-dione In the manner described in Example 1–1), the entitled compound was obtained as colorless crystals from 2-iminopyrrolidine hydrochloride and phenoxycarbonylisocyanate. Melting Point: 201-202 C. NMR Spectrum (DMSO-d6): 2.87 (2H, t), 2.07 (2H, t), 3.82 (2H, t), 11.25 (1H, bs) IR Spectrum nu (KBr) cm-1: 3430, 3210, 3080, 1740, 1710, 1690, 1630, 1440, 1410

The synthetic route of 7544-75-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Daiichi Pharmaceutical Co., Ltd.; US5232924; (1993); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem