With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.
To a stirred solution of 2,3-dibromomaleimide (0.255 g, 1.0mmol) in tetrahydrofuran (4 ml) N-methylmorpholine (76 mul, 1.1mmol) and methyl chloroformate (85 mul, 1.1mmol) were added at 0 C. When TLC (nhexane:acetone=8:2) showed complete conversion of the starting material(3 h), the reaction mixture was diluted with CH2Cl2, filtered through a pad ofCelite and evaporated. The obtained crude 4 (0.308 g) was reacted, withoutpurification, with t-butyl mercaptan 2g (237 mul, 2.1mmol) according to generalmethod A to give compound 6g (0.150 g). The crude product was used forfurther step without purification.
1122-10-7, As the paragraph descriping shows that 1122-10-7 is playing an increasingly important role.
Reference£º
Article; Csavas, Magdolna; Miskovics, Adrienn; Szcs, Zsolt; Rth, Erzsebet; Nagy, Zsolt L; Bereczki, Ilona; Herczeg, Mihaly; Batta, Gyula; Nemes-Nikodem, Eva; Ostorhazi, Eszter; Rozgonyi, Ferenc; Borbas, Aniko; Herczegh, Pal; Journal of Antibiotics; vol. 68; 9; (2015); p. 579 – 585;,
Pyrroline – Wikipedia
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