With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31970-04-4,Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.
Benzyl 2,5-dihydro-lH-pyrrole-l-carboxylate (0.88 g, 4.33 mmol) was dissolved in a mixture of TEtaF (20 mL) and water (5 mL) and the resulting solution was cooled to 0 0C. NMO (0.558 g, 4.76 mmol) and OsO4 (13 mg, cat) were added and the reaction was stirred for 18 h at ambient temperature. The reaction was washed with water (15 mL) and extracted with EtOAc (3 x 20 mL). The combined organic extracts were washed with brine (10 mL), dried over Na2SO4 and concentrated in vacuo. The resulting residue was purified by FCC eluting with 30 percent EtOAc in hexane to afford the title compound. Yield: 0.85 g, 83 percent.
31970-04-4, The synthetic route of 31970-04-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; EVOTEC NEUROSCIENCES GMBH; MADDEN, James; HALLETT, David James; PARKES, Alastair; RAOOF, Ali; WANG, Xialou; WO2010/20556; (2010); A1;,
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