5264-35-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5264-35-7,5-Methoxy-3,4-dihydro-2H-pyrrole,as a common compound, the synthetic route is as follows.
5-Methoxy-3,4-dihydro-2H-pyrrole (220mg) was combined with 8- isoquinolinamine (320 mg) (CAS 23687-27-6) in 10 mL of methanol in the presence of catalytic amount of AcOH. The reaction was stirred at 70¡ãC for 18 hours. The reaction was then cooled to room temperature and concentrated. Flash column chromatography (2-4percent 7N NH3 in MeOH/DCM) yielded the title compound. 1 H NMR (300 MHz, CD3OD) delta: 2.33 (m, 2H), 3.20 (m, 2H), 3.70 (t, J=3.33Hz, 2H), 7.72 (dd, J=0.88Hz 7.33Hz,1 H), 7.89 (t, J=7.33Hz, 1 H), 7.95 (dd, J=0.88Hz 5.86Hz, 1 H), 8.04 (d, J=8.50Hz, 1 H), 8.58 (d, J=5.86Hz, 1 H), 9.39 (d, J=0.88Hz, 1 H).
5264-35-7 5-Methoxy-3,4-dihydro-2H-pyrrole 353443, apyrrolines compound, is more and more widely used in various fields.
Reference£º
Patent; ALLERGAN, INC.; CHOW, Ken; GIL, Daniel W.; DONELLO, John E.; WANG, Liming; CORPUZ, Evelyn G.; FANG, Wenkui K.; SINHA, Santosh C.; DIBAS, Mohammed I.; WO2011/44229; (2011); A1;,
Pyrroline – Wikipedia
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