5264-35-7, 5-Methoxy-3,4-dihydro-2H-pyrrole is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5264-35-7
To a solution of ethyl N-[3-(3-amidinophenyl)-2-(E)-propenyl]-N-[3-chloro-4-(piperidin-4-yloxy)phenyl]sulfamoylacetate dihydrochloride (0.75 g) obtained in example 47(a) in ethanol (25 ml) were added successively 5-methoxy-3,4-dihydro-2H-pyrrole (0.25 g), which was prepared from 2-pyrrolidinone according to the method described in Org. Prep. Proced. Int., 24, 147 (1992), and triethylamine (0.69 ml) at room temperature, and the resulting mixture was stirred at room temperature for 10 hours and then allowed to stand at room temperature for 84 hours.. To the reaction mixture was added a 4N solution of hydrogen chloride in dioxane (10 ml) and the resulting mixture was evaporated in vacuo.. The residue obtained was purified by preparative HPLC (YMC-Pack ODS-A; YMC, eluent: 25 percent acetonitrile/water).. Subsequently, to a solution of the amorphous solid obtained in ethanol (10 ml) was added a 4N solution of hydrogen chloride in dioxane (2 ml), and the resulting mixture was evaporated to dryness in vacuo.. The residue obtained was dissolved in water and then lyophilized to afford the title compound (0.52 g, yield: 62 percent) as a colorless amorphous solid. 1H NMR (400MHz, DMSO-d6) delta ppm: 1.23 (3H, t, J=7.0), 1.75-1.86 (2H, m), 2.02-2.14 (4H, m), 2.97 (2H, t, J=8.0), 3.50-3.91 (6H, m), 4.19 (2H, q, J=7.0), 4.42 (2H, s), 4.47 (2H, d, J=6.0), 4.81-4.87 (1H, m), 6.45 (1H, dt, J=16.0, 6.0), 6.58 (1H, d, J=16.0), 7.34 (1H, d, J=9.0), 7.41 (1H, dd, J=9.0, 2.5), 7.55 (1H, t, J=8.0), 7.59 (1H, d, J=2.5), 7.70-7.74 (2H, m), 7.91 (1H, s); IR (KBr, cm-1): 1738, 1672, 1352, 1156.
5264-35-7 5-Methoxy-3,4-dihydro-2H-pyrrole 353443, apyrrolines compound, is more and more widely used in various fields.
Reference£º
Patent; Sankyo Company, Limited; EP1375482; (2004); A1;,
Pyrroline – Wikipedia
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