55750-48-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55750-48-6,Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.
A solution of amine 8 (23.9 mg, 29. 0 [JMOL)] dissolved in 1 M aqueous solution of NaHCO3 (1 mL) was treated with methoxycarbonylmaleimide (27.03 mg, 17. [4] pmol) at [0 C.] After 5 min, the mixture was diluted with water (1 [ML)] and acetonitrile (2 mL), and then stirred at room temperature for 1 h. The mixture was diluted with CH2Cl2 (50 mL) and washed with brine [(3X10] mL). The organic phase was dried over [NA2SO4,] filtered and concentrated. The oily residue was purified by flash chromatography [(CH2CL2/MEOH] 96: 4) to give maleimide 9 (20.3 mg, 71%) ; Rf 0. 45 [(CH2CL2/MEOH] 96: 4) [;’H-NMR (CDC13/TMS)] : [No.6. ]72 (s, 8 H, CH=CH), 4.94 (d, [1] H, J=3. 4 Hz, [H-1),] 3.95-3. 82 (m, 2 H, H-4, and [OCHHCH2CH2N),] 3. [80No.3. ]45 (m, 22 H, H-2, H-3, H-5, H-6, H-6′, [OCH2CH2CH2S,] SCH2CH2N, and [OCH2CH3),] 2.90-2. 60 (m, 16 H, [OCH2CH2CH2SCH2CH2N),] 1.96-1. 82 (m, 8 H, OCH2CH2CH2S), 1.23 (t, 3 H, J=7.1 Hz, OCH2CH3) ; ES-MS: 1019.49 (M+Na) [+,] 951 (M-OEt) +.
As the paragraph descriping shows that 55750-48-6 is playing an increasingly important role.
Reference£º
Patent; UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE; WO2004/802; (2003); A2;,
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