55750-48-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55750-48-6,Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.
[4321] 22.5 mg (20 f.tmol) oflntermediate 101 were takenup in 2 ml ofl : 1 dioxane/water and then admixed with 5. 6 mg(40 f.tmol) of methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate and with 0.25 ml of saturated sodium hydrogencarbonatesolution. The reaction mixture was stirred at RT for30 min. Then another 0.25 ml of the saturated sodium hydrogencarbonatesolution were added, and the reaction mixturewas stirred at RT for another 15 min and then concentrated invacuo. The remaining residue was purified by means of preparativeHPLC.Afterlyophilization, 12.8mg(50%oftheory)of the title compound were obtained as a colourless foam.[4322] HPLC (Method 5): R,=l.9 min;[4323] LC-MS (Method 1): R,=0.95 min; MS (ESipos):rnz=1019 (M+Hr.
As the paragraph descriping shows that 55750-48-6 is playing an increasingly important role.
Reference£º
Patent; SEATTLE GENETICS, INC.; LERCHEN, Hans-Georg; LINDEN, Lars; SHEIKH, Sherif El; WILLUDA, Joerg; KOPITZ, Charlotte C.; SCHUHMACHER, Joachim; GREVEN, Simone; MAHLERT, Christoph; STELTE-LUDWIG, Beatrix; GOLFIER, Sven; BEIER, Rudolf; HEISLER, Iring; HARRENGA, Axel; THIERAUCH, Karl-Heinz; BRUDER, Sandra; PETRUL, Heike; JOeRISSEN, Hannah; BORKOWSKI, Sandra; US2015/246136; (2015); A1;,
Pyrroline – Wikipedia
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