With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55750-48-6,Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.
55750-48-6, Using a 40 mL vial, a solution of prop-2-yn-1 -amine (500 mg, 9.08 mmol) in 15 mL of sat. aqueous NaHC03 was cooled to 0 C with ice bath and then methyl 2,5-dioxo-2,5-dihydro-1 H- pyrrole-1 -carboxylate (1 .27 g, 8.17 mmol) was added. The reaction mixture was then stirred at the same temperature for 4 h and then extracted wtih 50 mL of CH2CI2 three times. The combined organic layers were dried over Na2S04, concentrated, purified by ISCO (24 g, silica gel) and concentrated to give 1 -(prop-2-yn-1 -yl)-1 H-pyrrole-2,5-dione (i-5). 1 H-NMR (CDCI3, 400 MHz) delta 6.76 (s, 2H), 4.29 (d, 2H, J = 2.8 Hz), 2.21 (t, 1 H, J=2.8 Hz).
The synthetic route of 55750-48-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NOVARTIS AG; BURGER, Matthew T.; JIN, Yunho; UNO, Tetsuo; (202 pag.)WO2017/191579; (2017); A1;,
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