With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5264-35-7,5-Methoxy-3,4-dihydro-2H-pyrrole,as a common compound, the synthetic route is as follows.
5264-35-7, To 1-(2,3-dichlorophenyl)-2-(pyridin-3-yl)ethanamine (258 mg, 0.97 mmol) in methanol (5 mL) was added 5-methoxy-3,4-dihydro-2H-pyrrole (96 mg, 0.97 mmol) followed by acetic acid (2 drops). The mixture was heated at 70¡ã C. for 16 hours. The mixture was cooled to room temperature and methanol was removed. Purification by chromatography on silica gel (5percent 7N NH3 in MeOH/CH2Cl2) gave N-(1-(2,3-dichlorophenyl)-2-(pyridin-3-yl)ethyl)-3,4-dihydro-2H-pyrrol-5-amine (161 mg, 50percent) as an off white solid.1H NMR (300 MHz, CD3OD) delta 1.79-1.90 (m, 2H), 2.41-2.49 (m, 2H), 2.87-2.94 (m, 1H), 3.14-3.21 (m, 1H), 3.34-3.41 (m, 2H), 5.28-5.33 (m, 1H), 7.30-7.47 (m, 4H), 7.77-7.81 (m, 1H), 8.36-8.42 (m, 1H), 8.43 (s, 1H).
As the paragraph descriping shows that 5264-35-7 is playing an increasingly important role.
Reference£º
Patent; ALLERGAN, INC.; US2010/145061; (2010); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem