With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5264-35-7,5-Methoxy-3,4-dihydro-2H-pyrrole,as a common compound, the synthetic route is as follows.
A 2L 3-necked flask equipped with a mechanical stirrer was charged with ethyl 2-amino-1 /-/-pyrrole-3-carboxylate (100 g, 0.648 mol) and 5-methoxy-3,4-dihydro-2/-/-pyrrole (128.6 g, 1.5 mol) and the mixture was stirred at 90¡ãC. After 8 h, 5-methoxy-3,4-dihydro-2H-pyrrole (45 g, 0.454 mol) was added then the mixture was kept at the same temperature overnight. It was purged with argon for 4 h then cooled to room temperature (rt). EtOAc (1 L) was added, the mixture was sonicated for 1 h and left to stand at rt overnight. The suspension was stirred for 4 h, then filtered. The solid was washed with EtOAc and dried to afford 1 ,6,7,8-tetrahydro-4H-dipyrrolo[1 ,2-a:2′,3′-d]pyrimidin-4-one as a greenish solid (96.8 g, 85.3 percent yield); LCMS [M+H]+ 176., 5264-35-7
5264-35-7 5-Methoxy-3,4-dihydro-2H-pyrrole 353443, apyrrolines compound, is more and more widely used in various fields.
Reference£º
Patent; ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR); AL-AWAR, Rima; ISAAC, Methvin; CHAU, Anh My; MAMAI, Ahmed; WATSON, Iain; PODA, Gennady; SUBRAMANIAN, Pandiaraju; WILSON, Brian; UEHLING, David; (191 pag.)WO2019/119145; (2019); A1;,
Pyrroline – Wikipedia
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