With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30364-60-4,Bis(2,5-dioxopyrrolidin-1-yl) succinate,as a common compound, the synthetic route is as follows.
To a solution of N-(2-(2-(2-(2 ammoethoxy)ethoxy)ethoxy)ethyl)- 4-(6,8-dichloro-2-methyl-l,2,3,4-tetrahydroisoquinolin-4 yl)benzenesulfonamide (compound 82) (200 mg, 0 37 mmol) in dry DMF (10 mL) under N2 was added bis(2,5- dioxopyrrolidm-1-yl) succinate (intermediate 177 1) (57 1 mg, 0 18 mmol) and triethylamine (111 mg, 1 10 mmol) The resulting solution was stirred for 4 h at 250C in an oil bath and monitored by LCMS The resulting mixture was concentrated under vacuum and the crude product was purified by Prep-HPLC with acetonitnle water (0 05% CF3COOH)(28%-35%) This resulted m 113 8 mg (45%) of the title compound as a TFA salt 1H-NMR (300MHz, CD3OD, ppm) 7 93-7 91 (d, J-8 IHz, 4H), 7 58- 7 57 (m, 2H), 7 50-748(m, 4H), 6 87 (s, 2H), 4 88-474 (m, 4H), 4 55-4 49 (d, ./=16 2Hz, 2H), 3 94-3 88 (m, 2H), 3 67-3 59 (m, 14H), 3 55-3 45 (m, 12H), 3 35-3 09 (m, 10H), 2 48 (s, 4H) LC-MS (ES, m/z) 588 [(M+2H)/2]+.
30364-60-4, 30364-60-4 Bis(2,5-dioxopyrrolidin-1-yl) succinate 161662, apyrrolidine compound, is more and more widely used in various fields.
Reference£º
Patent; ARDELYX, INC.; CHARMOT, Dominique; JACOBS, Jeffrey, W.; LEADBETTER, Michael, Robert; NAVRE, Marc; CARRERAS, Chris; BELL, Noah; WO2010/78449; (2010); A2;,
Pyrrolidine – Wikipedia
Pyrrolidine | C4H9N – PubChem