With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50609-01-3,4-(2-(Pyrrolidin-1-yl)ethoxy)aniline,as a common compound, the synthetic route is as follows.
To a round bottom flask was added 6-chloro-4- (S) – (tetrahydrofuran-2-yl) methylaminopyrimidine (0.1 g, 0.468 mmol)And 4- (2- (pyrrolidin-1-yl) ethoxy) aniline (0.088 mL, 0.468 mmol) was dissolved in 2-methoxyethanol (5 mL), a hydrochloric acid solution (4M dioxane solution, 0.1 mL) was added, and the mixture was stirred at 110 DEG C for 24 hours. When the reaction was completed, the solvent was removed by distillation under reduced pressure, and a saturated aqueous solution of sodium hydrogencarbonate was added to the reaction mixture, followed by extraction with dichloromethane. After drying over anhydrous magnesium sulfate, the solvent was removed by distillation under reduced pressure, and the resultant product was purified by column chromatography to obtain the title compound (0.095 g, 53%)., 50609-01-3
As the paragraph descriping shows that 50609-01-3 is playing an increasingly important role.
Reference£º
Patent; Korea Institute of Science and Technology; Lee So-ha; Ryu Gyeong-ho; Kim Tae-yeong; Ho Seu-ni-al-ri-, -e-seu-ram-mo-ha-me-deu; (27 pag.)KR101916773; (2018); B1;,
Pyrrolidine – Wikipedia
Pyrrolidine | C4H9N – PubChem