With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5264-35-7,5-Methoxy-3,4-dihydro-2H-pyrrole,as a common compound, the synthetic route is as follows.,5264-35-7
To a solution of ethyl N-[3-(3-amidinophenyl)-2-fluoro-2-(Z)-propenyl]-N-[3-carbamoyl-4-(piperidin-4-yloxy)phenyl]sulfamoylacetate (1.20 g) obtained in example 99(a) in ethanol (40 ml) were added successively 5-methoxy-3,4-dihydro-2H-pyrrole, (0.64 g), which was prepared from 2-pyrrolidinone according to the method described in Org. Prep. Proced. Int., 24, 147 (1992), and triethylamine (1.80 ml) at room temperature, and the resulting mixture was stirred at room temperature for 1 hour and allowed to stand at room temperature overnight and then evaporated in vacuo.. The residue obtained was purified by preparative HPLC (YMC-Pack ODS-A; YMC, eluent: 15 percent acetonitrile/water).. Subsequently, to a solution of the amorphous solid obtained in ethanol (5 ml) was added a 4N solution of hydrogen chloride in dioxane (1.60 ml), and the resulting mixture was evaporated to dryness in vacuo to afford the title compound (0.40 g, yield: 26 percent) as a colorless amorphous solid. 1H NMR (500MHz, DMSO-d6) delta ppm: 1.24 (3H, t, J=7.0), 1.81-1.92 (2H, m), 2.02-2.14 (4H, m), 2.96 (2H, t, J=8.0), 3.48-3.88 (6H, m), 4.21 (2H, q, J=7.0), 4.40 (2H, s), 4.62 (2H, d, J=16.0), 4.87 (1H, m), 5.98 (1H, d, J=39.0), 7.30 (1H, d, J=9.0), 7.49-7.63 (2H, m), 7.68 (1H, d, J=8.0), 7.74-7.82 (3H, m); IR (KBr, cm-1): 1669, 1354, 1156.
The synthetic route of 5264-35-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Sankyo Company, Limited; EP1375482; (2004); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem