With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5264-35-7,5-Methoxy-3,4-dihydro-2H-pyrrole,as a common compound, the synthetic route is as follows.
5264-35-7, A flame dried flask was charged with a 0.5 M solution of 5-methoxy-3,4- dihydro-2//-pyrrole (which had been passed through a plug OfNa2SO4 prior to its usage) (1.00 g, 10.1 mmol, 1.01 equiv.) in anhydrous methanol and mesityl hydrazine hydrochloride (1.87 g, 10.0 mmol, 1.00 equiv.) was added. The solution was heated to 50 0C and conversion to the product monitored by IHNMR, (ca 30 min.), during this time it had became deep red in color. The solution was cooled to room temperature and concentrated in vacuo to the crude solid which was subsequently twice recrystallized from 200 proof EtOH to afford the title compound as a white powder (1.64 g, 6.5 mmol, 65percent yield). 1H NMR (400 MHz, DMSO) delta 10.87 (s,lH), 10.08 (s, IH), 7.14 (s, I H), 6.86 (s, 2H), 3.63 (t, 2H, J= 8.0 Hz), 2.81 (t, 2H, J= 8.0 Hz), 2.19 (s, 6H), 2.18 (s, 3H), 2.15 (shoulder, m, 2H); HRESI+/TOF-MS calcd for C13H20N3+ [M]+ 218.1652; found, 218.1646
5264-35-7 5-Methoxy-3,4-dihydro-2H-pyrrole 353443, apyrrolines compound, is more and more widely used in various fields.
Reference£º
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; WO2007/124494; (2007); A2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem